Evidence map›Paper›PMID 41535541›Full record

ArticleCellular & molecular immunology2026

tRNA m

Xuefei Wang, Xudong Wang, Hao Li, Shuyu Liu, Yang Lu, Huifang Chen, Xueming Cai, Siyu Su, Bin Li, Rujuan Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xuefei Wang *Department of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xudong Wang *Liangzhu Laboratory, Zhejiang University, Hangzhou, 311121, China.
Hao Li *School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Shuyu LiuEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Yang LuChongqing International Institute for Immunology, Chongqing, 401320, China.ORCID 0009-0002-4104-6382
Huifang ChenShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xueming CaiShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Siyu SuLiangzhu Laboratory, Zhejiang University, Hangzhou, 311121, China.
Bin LiShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.ORCID 0000-0002-7640-8884
Rujuan LiuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Weiguo HuDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. wghu@rjh.com.cn.ORCID 0000-0003-2156-6233
Xiangjia ZhuEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. zhuxiangjia1982@126.com.
Jin ZhangLiangzhu Laboratory, Zhejiang University, Hangzhou, 311121, China. zhgene@zju.edu.cn.
Youqiong YeShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. youqiong.ye@shsmu.edu.cn.ORCID 0000-0001-8332-4710
Hua-Bing LiDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. huabing.li@shsmu.edu.cn.ORCID 0000-0003-3573-6803

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFA1100800Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2025YFC3410100National Natural Science Foundation of China (National Science Foundation of China) 32400747National Natural Science Foundation of China (National Science Foundation of China) 82030042National Natural Science Foundation of China (National Science Foundation of China) 82325024National Natural Science Foundation of China (National Science Foundation of China) 82341017National Natural Science Foundation of China (National Science Foundation of China) 82350112National Natural Science Foundation of China (National Science Foundation of China) 82441048National Natural Science Foundation of China (National Science Foundation of China) 82461160323
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) play crucial roles in tumor progression. However, the mechanisms underlying the posttranscriptional regulation of TAMs remain largely unknown. Here, we demonstrated that Trmt61a, the "writer" enzyme of tRNA N1-methyladenosine (m

Indexed as

ImmunotherapyMacrophagesMembrane ProteinsNeoplasmsProtein BiosynthesisRNA, TransfertRNA MethyltransferasesAnimalsCell Line, TumorcGAS-STING Signaling PathwayHumansMiceMice, Inbred C57BLMice, KnockoutProtein Serine-Threonine KinasesRNA MethylationMembrane ProteinsProtein Serine-Threonine KinasesRNA, TransferSting1 protein, mouseSTING ProteintRNA MethyltransferasesMacrophagesSTINGTRMT61AtRNA m1A modificationTumor immunotherapy

Identifiers

PMID41535541
PMCPMC12949049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.