Novel DCAT plans in stereotactic body radiotherapy for stage I/II centrally located non-small-cell lung cancer.

Yangyang Huang, Jun Yang, Cheng Wang, Jinghui Yang, Ge Hou, Chengzhang Long, Yibao Liu

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yangyang Huang *Department of Radiotherapy, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan Province, China.

Jun Yang *Department of Radiotherapy, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

Cheng WangDepartment of Radiotherapy, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan Province, China.

Jinghui YangDepartment of Radiotherapy, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan Province, China.

Ge HouDepartment of Radiotherapy, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan Province, China.

Chengzhang LongHenan Institute of Metrology, Zhengzhou, 450008, Henan Province, China. 9891766@qq.com.

Yibao LiuSchool of Nuclear Science and Engineering, East China University of Technology, Nanchang, 330013, Jiangxi Province, China. lyb01@tsinghua.org.cn.

Funding

Henan Province Medical Science and Technology Project LHGJ20210407Henan Province Science and Technology Development Project 232102310091Key Scientific Research Project of Colleges and Universities in Henan Province 25B320023National Natural Science Foundation of China 11965001

6 · The paper itself

Abstract

This study evaluated the feasibility of a novel dynamic conformal arc therapy (DCAT) plan, based on segment shape optimization (SSO) and variable dose rate (VDR), versus volumetric modulated arc therapy (VMAT) for stereotactic body radiotherapy (SBRT) in stage I/II centrally located non-small-cell lung cancer (NSCLC) per RTOG 0813. Twenty-five patients with PTV < 70 cc were retrospectively analyzed, with both plans using identical parameters in Monaco. Both plans met RTOG 0813 criteria. DCAT showed increased ipsilateral and total lung dose but no significant differences in most other organs at risk (OARs) (P > 0.05). DCAT significantly reduced segments (median 19.38%), monitor units (MUs, median 23.27%), and beam-on time (BOT, median 8.80 s; P < 0.05). Its γ passing rate (2%, 1 mm) was higher (93.70% vs. VMAT 91.90%, P < 0.05). Larger PTV volumes improved DCAT's heterogeneity index (HI) and segment advantages but worsened R

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiosurgeryRadiotherapy Planning, Computer-AssistedAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingOrgans at RiskRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesDCATRTOG 0813SBRTStage I/II centrally located non-small-cell lung cancerVMAT

Identifiers

PMID41535532

DOI10.1038/s41598-026-35713-0

PMCPMC12881350

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.