Evidence map›Paper›PMID 41535489›Full record

ReviewNature2026

Enriching African genome representation through the AGenDA project.

M Ramsay, H Etheredge, F Tluway, M E D'Amato, Z Chikwambi, Y Hamdi, I Alhudiri, Y Fakim, K M Ahmad, N Belguith and 52 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors.

M RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. michele.ramsay@wits.ac.za.ORCID 0000-0002-4156-4801
H EtheredgeSteve Biko Centre for Bioethics, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa.
F TluwaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-3130-3616
M E D'AmatoForensic DNA Lab, Biotechnology Department, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa.ORCID 0000-0003-0990-0219
Z ChikwambiAfrican Institute of Biomedical Sciences and Technology, Harare, Zimbabwe.
Y HamdiLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.
I AlhudiriGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.
Y FakimUniversity of Mauritius, Réduit, Mauritius.
K M AhmadDepartment of Microbiology, Faculty of Medicine, Sebha University, Sebha, Libya.
N BelguithDepartment of Genetics, Hôpital Charles Nicolle de Tunis, Tunis, Tunisia.ORCID 0000-0001-6821-1574
D BentleyIllumina Centre, Cambridge, UK.
M BoujemaaLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.ORCID 0000-0001-7409-9240
N CalumbuanaDepartment of Chemistry, Clinical Pathology and Genetics, Medical School, Agostinho Neto University, Luanda, Angola.ORCID 0009-0008-9419-8404
M ChaouchLaboratory of Bioinformatics, Biomathematics and Biostatistics (LR 16 IPT 09), Institut Pasteur de Tunis, Tunis, Tunisia.ORCID 0000-0001-5868-4204
C CharfeddineLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.ORCID 0000-0002-4656-2661
G ChinienUniversity of Mauritius, Réduit, Mauritius.
N DukuzeDepartment of Pediatrics-Clinical Genetics, Rwanda Military Referral and Teaching Hospital, Kigali, Rwanda.
M EljilaniGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.ORCID 0000-0001-6460-1890
A ElzagheidGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.
N FerrazDepartment of Chemistry, Clinical Pathology and Genetics, Medical School, Agostinho Neto University, Luanda, Angola.ORCID 0009-0000-9699-9223
A GhoorahUniversity of Mauritius, Réduit, Mauritius.ORCID 0000-0001-8273-6000
S GoorahUniversity of Mauritius, Réduit, Mauritius.
M GribaaFaculty of Medicine, University of Sousse, Sousse, Tunisia.
S GuidaraDepartment of Human Genetics, Hedi Chaker Hospital, Sfax, Tunisia.
M GuiratDepartment of Medical Genetics, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
S HazelhurstSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-0581-149X
M JallulGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.
M KasuForensic DNA Lab, Biotechnology Department, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa.ORCID 0000-0003-0899-2254
N KharratLaboratory of Molecular and Cellular Screening Process (LR15CBS07), Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.
U KhumaloAfrican Institute of Biomedical Sciences and Technology, Harare, Zimbabwe.
Z KingsburyIllumina Centre, Cambridge, UK.
I KisianganiAfrican Population and Health Research Center, Nairobi, Kenya.ORCID 0000-0002-1107-4334
I Lopes-CendesDepartment of Medical Genetics, School of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil.ORCID 0000-0002-6221-6822
P LukusaCenter for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.ORCID 0000-0002-5414-2915
P MakayCenter for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.ORCID 0000-0002-2910-9590
J MakuloNephrology Unit, Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
G MubunguCenter for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.ORCID 0000-0002-8870-0575
C MuhindaCenter for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.ORCID 0000-0003-2290-4409
D M MukhongoDepartment of Biological and Environmental Sciences Research, Kabii University, Bungoma, Kenya.ORCID 0000-0001-7248-8672
A MurwiraSchool of Business, Leadership and Governance, Africa University, Mutare, Zimbabwe.
A MustafaGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.ORCID 0000-0001-9678-2243
J NdinkabandiCenter for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
M NgoleCenter for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Y NlanduNephrology Unit, Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
M NyathiTsholotsho District Hospital, Tsholotsho, Zimbabwe.
L Pereirai3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.ORCID 0000-0002-4271-1527
I RejebDepartment of Genetics, Mongi Slim Hospital, La Marsa, Tunisia.ORCID 0000-0002-2826-1910
L L SantosExperimental Pathology and Therapeutics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Porto, Portugal.
D SenguptaSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-6315-7804
A ShebaniGenetic Engineering Department, Libyan Biotechnology Research Center, Tripoli, Libya.
N SmythSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-7870-4057
A SouissiLaboratory of Molecular and Cellular Screening Process (LR15CBS07), Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.ORCID 0000-0003-3838-1876
M TrabelsiDepartment of Genetics, Charles Nicolle Hospital, Tunis, Tunisia.
A RebaiLaboratory of Molecular and Cellular Screening Process (LR15CBS07), Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.
M M ChimpoloDepartment of Chemistry, Clinical Pathology and Genetics, Medical School, Agostinho Neto University, Luanda, Angola.ORCID 0000-0002-8986-5195
A LumakaCenter for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
C MasimirembwaAfrican Institute of Biomedical Sciences and Technology, Harare, Zimbabwe.
S F MohamedAfrican Population and Health Research Center, Nairobi, Kenya.ORCID 0000-0002-8693-1943
N MulderComputational Biology Division, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4905-0941
L MutesaDepartment of Pediatrics-Clinical Genetics, Rwanda Military Referral and Teaching Hospital, Kigali, Rwanda.ORCID 0000-0002-5308-3706
N A HanchardChildhood Complex Disease Genomics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
A ChoudhurySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-8225-9531

Funding

Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2M
Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry - Study SitesU01HG011717 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI ADEBAMOWO, SALLY NNEOMA, TAYO, BAMIDELE OLUSEGUN · 2021 to 2025
$4.6M
Integrated modeLs for Early Risk-prediction in Africa (ILERA) studyU01HL172182 · NHLBI · WITS HEALTH CONSORTIUM (PTY), LTD · PI CHOUDHURY, ANANYO · 2023 to 2025
$750k
NHGRI NIH HHS U01 HG011717NHGRI NIH HHS U54 HG006938NHLBI NIH HHS U01 HL172182
6 · The paper itself

Abstract

African populations remain substantially under-represented in research studies and global genomic databases. As the ancestral home of anatomically modern humans, Africa holds pride of place regarding human genetic diversity, with a deep and complex evolution over hundreds of thousands of years of human migration, admixture, and exposure to climate changes and infectious agents. Yet our present view of genomic diversity in Africa is sparse and poorly captures the rich variation across its more than 2,000 ethnolinguistic groups. To enhance representation, the Assessing Genetic Diversity in Africa (AGenDA) project, under the umbrella of the Human Heredity and Health in Africa (H3Africa) consortium, identified under-represented groups across nine different African countries for human whole-genome sequencing, with a view to enriching global datasets. Here we share our processes, including community engagement, obtaining ethics approvals, navigating legal compliance and developing a common governance framework. AGenDA is a testament to the determination of the scientific community to undertake research in challenging environments. It is led from Africa by African investigators who are the decision-makers in data-sharing processes. AGenDA is a step towards greater African representation in global genomic datasets to advance genomic research towards enabling precision medicine for Africa and the world.

Indexed as

Black PeopleGenetic VariationGenome, HumanGenomicsAfricaHumansInformation DisseminationPrecision MedicineWhole Genome Sequencing

Identifiers

PMID41535489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.