Evidence map›Paper›PMID 41535469›Full record

ArticleNature2026

Disease tolerance and infection pathogenesis age-related tradeoffs in mice.

Karina K Sanchez, Justin L McCarville, Sarah J Stengel, Jessica M Snyder, April E Williams, Janelle S Ayres

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karina K Sanchez *Molecular and Systems Physiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Justin L McCarville *Molecular and Systems Physiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Sarah J StengelMolecular and Systems Physiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jessica M SnyderDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
April E WilliamsThe Razavi Newman Integrative Genomics and Bioinformatics Core Facility, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-9281-8528
Janelle S AyresMolecular and Systems Physiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. jayres@salk.edu.ORCID 0000-0002-0809-2494

Funding

Host-microbe interactions: Harnessing co-evolution to treat diseaseDP1AI144249 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2018 to 2022
$6.7M
Tolerance defenses in host-microbiota interactionsR01AI114929 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2015 to 2025
$4.9M
NIAID NIH HHS DP1 AI144249NIAID NIH HHS R01 AI114929
6 · The paper itself

Abstract

Disease tolerance is a defence strategy essential for survival of infections, limiting physiological damage without killing the pathogen

Indexed as

AgingImmune ToleranceInfectionsAge FactorsAnimalsDisease Models, AnimalFemaleForkhead Box Protein O1MaleMiceMice, Inbred C57BLMultiple Organ FailureMyocardiumSepsisForkhead Box Protein O1Foxo1 protein, mouse

Identifiers

PMID41535469
PMCPMC12916300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.