ArticleNature2026
Language model-guided anticipation and discovery of mammalian metabolites.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Envisioning AI-empowered ecological, environmental, and health protection: Welcome submissions of interdisciplinary research.Eco-Environment & Health · 2026Article
- Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz.Molecular systems biology · 2026Article
- Trends in Computational Metabolomics: A Perspective on Five Years of Software Development, Challenges, and Opportunities (2021-2025).Analytical chemistry · 2026Review
- A historical journey of metabolite-protein interaction discovery: from data harmonization to AI-driven prediction.Briefings in bioinformatics · 2026Review
- Leveraging 13C-Labeling to Assign Molecular Formulas to Unknown Yeast Metabolites.Journal of the American Society for Mass Spectrometry · 2026Article
- The Language of Elution: Autoregressive Prediction of the Next Feature in Untargeted LC-HRMS Lipidomics.ArXiv · 2026Article
- Combating Antibacterial Resistance: The Integrative Role of Artificial Intelligence in Bio-Based Product Development.Antibiotics (Basel, Switzerland) · 2026Review
- Structure-informed deep generation enables de novo metabolite annotation in untargeted metabolomics.Nature communications · 2026Article
- Mapping the mammalian dark metabolome bybioRxiv : the preprint server for biology · 2026Article
- Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells.Nature metabolism · 2026Article
- Comprehensive Curation and Harmonization of Small-Molecule MS/MS Libraries in Spectraverse.Analytical chemistry · 2026Article
- Navigating the conjugated metabolome.bioRxiv : the preprint server for biology · 2026Article
- Review
- Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
31 authors.
Hantao Qiang *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0009-0006-9479-6717
Fei Wang *Department of Computing Science, University of Alberta, Edmonton, Alberta, Canada.
Wenyun LuLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-1787-2617
Xi XingLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Hahn KimLudwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Sandrine A M MéretteProvincial Toxicology Centre, Provincial Health Services Authority, Vancouver, BC, Canada.
Lucas B AyresLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Eponine OlerDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Jenna E AbuSalimLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Asael RoichmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Michael NeinastLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ricardo A CordovaLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Won Dong LeeLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-2344-171X
Ehud HerbstLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-5570-5804
Vishu GuptaLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Samuel L NeffLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-5993-8445
Mickel Hiebert-GiesbrechtDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-2947-187X
Adamo YoungDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Vasuk GautamDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Siyang TianDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Bo WangDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9620-3413
Hannes RöstDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0990-7488
Jatinder BaidwanBC Coroners Service, Burnaby, British Columbia, Canada.
Russell GreinerDepartment of Computing Science, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-8327-934X
Li ChenShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.ORCID 0000-0001-8685-3466
Chad W JohnstonDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
Leonard J FosterMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-8551-4817
Aaron M ShapiroProvincial Toxicology Centre, Provincial Health Services Authority, Vancouver, BC, Canada.ORCID 0000-0002-9920-1763
David S WishartDepartment of Computing Science, University of Alberta, Edmonton, Alberta, Canada.
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-1247-4727
Michael A SkinniderLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. skinnider@princeton.edu.ORCID 0000-0002-2168-1621
Funding
Revealing cancer metabolism via mass spectrometry and isotope tracersR50CA211437 · NCI · PRINCETON UNIVERSITY · PI Wenyun Lu · 2016 to 2026
$1.3MNCI NIH HHS R50 CA211437
Abstract
Despite decades of study, large parts of the mammalian metabolome remain unexplored
Indexed as
MammalsMetabolomicsModels, ChemicalAnimalsHumansMass SpectrometryMetabolome
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.