Evidence map›Paper›PMID 41535461›Full record

ArticleNature2026

CFAP20 salvages arrested RNAPII from the path of co-directional replisomes.

Sidrit Uruci, Daphne E C Boer, Paul W Chrystal, Maxime Lalonde, Andreas Panagopoulos, George Yakoub, Idil Kirdök, Klaas de Lint, Melanie van der Woude, Tiemen J Wendel and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Sidrit Uruci *Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3248-7960
Daphne E C Boer *Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3446-7795
Paul W ChrystalDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5371-1178
Maxime LalondeInstitute of Epigenetics and Stem Cells, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0002-0495-8967
Andreas PanagopoulosDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7787-6938
George YakoubDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2727-7651
Idil KirdökDepartment of Human Genetics and Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Klaas de LintDepartment of Human Genetics and Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0001-7134-444X
Melanie van der WoudeDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2043-8563
Tiemen J WendelDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0009-0006-1434-2396
Sem J BrusseeDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7633-1293
Annelotte P WondergemDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Nila K van OverbeekDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0431-3595
Nini SchotmanDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0009-0008-4315-3396
Jolanthe LingemanDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-8199-1157
Mats LjungmanDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1553-6695
Alexander van OudenaardenOncode Institute, Utrecht, The Netherlands.ORCID 0000-0002-9442-3551
Haico van AttikumDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Alfred C O VertegaalDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Sylvie M NoordermeerDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2737-9690
Rob M F WolthuisDepartment of Human Genetics and Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Matthias AltmeyerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3780-1170
Stephan HamperlInstitute of Epigenetics and Stem Cells, Helmholtz Center Munich, Munich, Germany.
Vincent TropepeDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Jeroen van den BergOncode Institute, Utrecht, The Netherlands.ORCID 0000-0002-9430-7155
Diana van den HeuvelDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. d.van_den_heuvel@lumc.nl.ORCID 0009-0003-6467-0943
Martijn S LuijsterburgDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. m.luijsterburg@lumc.nl.ORCID 0000-0001-5796-6541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fine-tuning DNA replication and transcription is crucial to prevent collisions between their machineries

Indexed as

Cytoskeletal ProteinsDNA ReplicationRNA Polymerase IIAnimalsCell LineGene Knockout TechniquesHumansPromoter Regions, GeneticReplication OriginR-Loop StructuresTranscription, GeneticZebrafishCytoskeletal ProteinsRNA Polymerase II

Identifiers

PMID41535461
PMCPMC12935552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.