Evidence map›Paper›PMID 41535459›Full record

ArticleNature2026

Microbiota-induced T cell plasticity enables immune-mediated tumour control.

Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  5. Article
  6. Review
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  8. Review
  9. Overcoming resistance to anti-PD-1/PD-L1 therapy in cancer.Cancer drug resistance (Alhambra, Calif.) · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tariq A NajarDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Yuan HaoDivision of Advanced Research Technologies, Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY, USA.
Yuhan HaoCenter for Genomics and Systems Biology, New York University, New York, NY, USA.
Gabriela Romero-MezaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Alexandra DolynukDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Emma AlmoDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Dan R LittmanDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA. dan.littman@med.nyu.edu.ORCID http://orcid.org/0000-0002-2850-8688

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaR01AI158687 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dan Littman · 2021 to 2026
$3.2M
Mechanism of microbiota-mediated potentiation of checkpoint blockade efficacy in lung cancerR01CA255635 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LITTMAN, DAN · 2021 to 2025
$2.8M
Scanning Electron Microscope with 3ViewS10OD019974 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, FENGXIA · 2016 to 2016
$1.1M
Inverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500k
NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA255635NCRR NIH HHS S10 RR023704NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS R01 AI158687NIDA NIH HHS 75N95020D00005NIH HHS 75N93023D00005NIH HHS 75N99020D00005NIH HHS S10 OD019974
6 · The paper itself

Abstract

Therapies that harness the immune system to target and eliminate tumour cells have revolutionized cancer care. Immune checkpoint blockade (ICB), which boosts the anti-tumour immune response by inhibiting negative regulators of T cell activation

Indexed as

Cell PlasticityGastrointestinal MicrobiomeTh17 CellsAnimalsFemaleHumansImmune Checkpoint InhibitorsImmunotherapyMaleMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorImmune Checkpoint InhibitorsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID41535459
PMCPMC12960244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.