Trial reportScientific reports2026
Effect of exercise on hormonal responses in adolescents with obesity and leptin resistance: a randomized trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Digital health literacy and disordered eating among adolescents: the chain mediating roles of physical activity and problematic social media use.Frontiers in psychiatry · 2026Article
- Physical exercise as a modulator of the sleep-obesity interaction: metabolic, neuroendocrine and circadian mechanisms.Frontiers in sleep · 2026Review
- Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study examined the effects of regular plyometric exercise on growth hormones, appetite hormones, myokines, and adipokines in adolescents with obesity and leptin resistance. Sixty adolescents (male: 11.9 ± 0.8 years; female: 13.0 ± 1.0 years) with body fat ≥ 30% and leptin ≥ 30 ng/mL participated between July 2023 and October 2024 following IRB approval. Participants were randomized by gender into control or exercise groups (n = 15 per gender). The exercise group completed a 12-week program (3 sessions/week, 150 min/week). Twelve participants withdrew (CON, n = 6; PE, n = 6). Thus, 48 participants completed the study and were included in the final per-protocol analysis. Assessments included body composition, muscle fitness (grip strength, isokinetic torque), and blood biomarkers. Significant improvements were observed in height, muscle mass, fat mass, body fat percentage, BMI, and muscle fitness in the exercise group (p < 0.05). GH and IGF-1 increased, with reduced myostatin and elevated follistatin (p < 0.05). Leptin sensitivity improved with increased adiponectin (p < 0.05). TNF-α showed no significant change. Findings suggest that plyometric exercise is an effective non-pharmacological approach to enhance growth, body composition, muscle fitness, and endocrine regulation in adolescents with obesity and leptin resistance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.