Evidence map›Paper›PMID 41535385›Full record

ArticleScientific reports2026

The gene-modulating power of Tannins isolated from Jatropha integerrima flowers on the transcriptomic profile of multidrug-resistant Klebsiella pneumoniae.

Fatma S Mahrous, Shimaa M Khalifa, Fatma Sayed Abdel-Aal Farag, Mona Shaban E M Badawy, Omnia Karem M Riad, Mona H Ibrahim, Maha M Soltan, Mohamed Marzouk

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fatma S MahrousDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.
Shimaa M KhalifaDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt. ShimaaKhalifa.52@azhar.edu.eg.ORCID http://orcid.org/0000-0003-3381-7036
Fatma Sayed Abdel-Aal FaragDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.
Mona Shaban E M BadawyDepartment of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.
Omnia Karem M RiadDepartment of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.
Mona H IbrahimDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt.
Maha M SoltanBiology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Institute, Chemistry of Medicinal Plants Department, National Research Centre, 33 El Bohouth St. (Former El-Tahrir St.), Dokki, Cairo, 12622, Egypt.
Mohamed MarzoukChemistry of Tanning Materials and Leather Technology Department, Chemical Industries Research Institute, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki, Cairo, 12622, Egypt. msmarzouk@yahoo.co.uk.ORCID http://orcid.org/0000-0002-1344-0617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The continuous increase in antibiotic resistance necessitates a global need to search for new sustainable antimicrobial agents, such as plant-delivered antimicrobial components. This study investigates the antimicrobial and antibiofilm properties of two tannins isolated from the flowers of Jatropha integerrima against multidrug-resistant Klebsiella pneumoniae. The two active tannins were isolated from the methanol-soluble portion of 70% aqueous methanol flower extract, by consecutive column chromatography. Their antimicrobial activity against the resistant K. pneumoniae isolate (BKP-122) was assessed through agar well diffusion and minimum inhibitory concentration (MIC) assays. Their antibiofilm activity was evaluated by using the microtiter plate method and real-time PCR to reveal their effect on the biofilm-associated genes.Their structures were identified as 2 hydrolysable ellagitannins, namely 1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-B

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialFlowersJatrophaKlebsiella pneumoniaeTanninsTranscriptomeBiofilmsGene Expression Regulation, BacterialHydrolyzable TanninsMicrobial Sensitivity TestsMolecular Docking SimulationPlant ExtractsAnti-Bacterial AgentsHydrolyzable TanninsPlant ExtractsTanninsBiofilmEllagitanninsEuphorbiaceaeGene-modulating powerJatropha integerrimaMultidrug-resistant Klebsiella pneumoniaNMR

Identifiers

PMID41535385
PMCPMC12808767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.