Evidence map›Paper›PMID 41535352›Full record

ArticleNPJ digital medicine2026

Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation.

Alireza Gharabaghi, Sergiu Groppa, Elena Casas, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S Feldman and 10 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071847 recruitingnot on this map

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

TypeobservationalSponsorAbbott Medical DevicesRan2019 to 2030Enrolled1,000ConditionsMovement Disorders, Parkinson Disease, Essential Tremor, TremorArmsDeep Brain Stimulation (DBS)
NCT05269862 naactive not recruitingnot on this map

Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation

TypeinterventionalSponsorAbbott Medical DevicesRan2022 to 2024Enrolled100ConditionsParkinson DiseaseArmsAbbott Infinity DBS systems with the NeuroSphere Virtual Clinic feature, Abbott Infinity DBS systems with the NeuroSphere Virtual Clinic feature (virtual clinic and in-clinic sessions)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Alireza GharabaghiInstitute for Neuromodulation and Neurotechnology, Faculty of Medicine, University Hospital Tübingen (UKT), University Tübingen, Tübingen, Germany. alireza.gharabaghi@uni-tuebingen.de.
Sergiu GroppaDepartment of Neurology, University Hospital Homburg, Homburg, Germany.
Elena CasasNeurosurgery Department, La Princesa University Hospital, Madrid, Spain.
Alfons SchnitzlerDepartment of Neurology, and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Laura Muñoz-DelgadoUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Vicky L MarshallDepartment of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK.
Jessica KarlDepartment of Neurological Sciences, Rush University, Chicago, IL, USA.
Lin ZhangDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.
Ramiro AlvarezDepartamento de Neurociencias, Unidad de Enfermedades Neurodegenerativas, Servicio de Neurologia, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
Mary S FeldmanDepartment of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Michael J SoileauTexas Movement Disorder Specialists, PLLC, Georgetown, TX, USA.
Lan LuoDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Benjamin L WalterDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Chengyuan WuDepartment of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Hong LeiDepartment of Neurology, University of Arizona, Tucson, AZ, USA.
Damian M HerzDepartment of Neurology, University Hospital Homburg, Homburg, Germany.
Devyani NanduriAbbott Neuromodulation, Austin, TX, USA.
Claudia A SalazarAbbott Neuromodulation, Austin, TX, USA.
Corneliu LucaDepartment of Neurology, University of Miami, Miami, FL, USA.
Daniel WeissCenter for Neurology, Department of Neurodegenerative Diseases, and Hertie Institute for Clinical Brain Research, University Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).

Identifiers

PMID41535352
PMCPMC12881580

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.