Evidence map›Paper›PMID 41535313›Full record

ArticleScientific reports2026

Modeling and inference of mixed dynamics and detection of causal emergent features.

William Casey, Leigh Metcalf, Shirshendu Chatterjee, Heeralal Janwa, Ernest Battifarano, April Edwards, Yaron Gvili

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William CaseyUnited States Naval Academy, Annapolis, MD, US. wcasey@usna.edu.
Leigh MetcalfCarnegie Mellon University, Pittsburgh, PA, US.
Shirshendu ChatterjeeCity University of New York, Graduate Center and City College, New York, NY, US.
Heeralal JanwaUniversity Puerto Rico, Río Piedras, San Juan, PR, US.
Ernest BattifaranoNew York University, New York, NY, US.
April EdwardsUnited States Naval Academy, Annapolis, MD, US.
Yaron GviliIndependent Scholar, Tel Aviv, Israel.

Funding

NASA 0NSSC22M0248National Science Foundation DMS 2154564
6 · The paper itself

Abstract

Many real-world problems feature nonlinear dynamic processes. Classical mathematical models may be adequate to describe a single dynamic process in isolation, but can be easily undermined by two natural and simple kinds of phenomenological variations: the emergence (or activation) of an additional dynamic process, and events that affect the parameters of an active process. COVID-19 data offers an important case study expressing these phenomenological variations that deeply challenge the classical SIR epidemiological model, and call for novel mathematical methods to detect and adapt to these critical variations. We address the modeling issues with a novel mathematical framework that reenvisions data as a mixture of multiple causal generating processes, each subject to possible parameter change-points. The new viewpoint extends nonlinear classical models in a manner that overcomes many of these types of phenomenological variations and enables a highly adaptive modeling closely linked to causal events. The new model space unifies a wider class of dynamics and is particularly effective at fitting multi-surge data and explaining key causal events related to surge origination. To demonstrate, we construct a mixture of logistic models termed the Adaptive Logistic Model (ALM), and then formulate appropriate nonlinear least squares optimization and regularization goals, and then apply ALM to data. To validate the approach, we return to COVID-19 forecasting (for case count), and compare ALM directly to other forecasting methods. ALM forecast accuracy is competitive with all leading forecast methods, but its greatest utility may be in how it detects changing dynamics (change-points) and retains far fewer but more interpretable parameters relating naturally to cause and intervening change. The method can be applied more generally as it adapts well to the multi-generative nature of many time series data problems. We demonstrate ALM robustness through data experiments in hydrology, economics, cybersecurity, and social media.

Indexed as

COVID-19Models, TheoreticalAlgorithmsHumansLogistic ModelsNonlinear DynamicsPandemicsSARS-CoV-2Causal inferenceChange-point analysisEpidemiologyForecastingLogistic equationMixture modelNonlinear least squaresTime series modeling

Identifiers

PMID41535313
PMCPMC12815911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.