Evidence map›Paper›PMID 41535255›Full record

ArticleOncogenesis2026

Rab37-mediated OPN secretion enriches SPP1

You-En Yang, Yu-An Lin, Lun-Ling Ling, I-Ying Kuo, Wan-Ting Kuo, Hsuan Liu, Yi-Ching Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

You-En YangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0003-1991-4179
Yu-An LinDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lun-Ling LingInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0007-1017-4230
I-Ying KuoDepartment of Biotechnology, College of Biomedical Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wan-Ting KuoInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsuan LiuDepartment of Cell and Molecular Biology, College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan, ROC.ORCID http://orcid.org/0000-0003-4691-2518
Yi-Ching WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ycw5798@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-7694-2067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated Macrophages (TAMs) are highly plastic immune cells that shape the tumor microenvironment (TME) and influence cancer progression. However, the molecular determinants governing their functional heterogeneity remain incompletely understood. In this study, we identify Rab37 as a key regulator that remodels the states of macrophages within the lung TME. Single-cell RNA sequencing revealed that Rab37 wild-type (WT) tumors were enriched in immunosuppressive Spp1

Identifiers

PMID41535255
PMCPMC12823564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.