SynthesisJournal of clinical periodontology2026
Efficacy of Biologics for Surgical Treatment of Periodontal Suprabony Defects: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.
Synthesis in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimLimited bone support in suprabony defects hinders predictable regeneration, but adjunctive biologics can improve results. This systematic review and meta-analysis aimed to evaluate the clinical efficacy of adjunctive biologics combined with open flap debridement (OFD) compared with OFD alone when treating suprabony defects. MATERIALS AND
methodsA systematic literature search was performed to identify controlled trials evaluating adult patients presenting horizontal periodontal defects. The primary outcome included residual probing depth (PD). Random-effects meta-analyses were performed; heterogeneity was assessed using I
resultsNine studies comprising 303 patients were included. Adjunctive use of biologics-including enamel matrix derivative (EMD), platelet-rich fibrin (PRF) and hyaluronic acid (HA)-significantly enhanced clinical outcomes compared to OFD alone, with pooled mean differences favouring EMD and PRF for both residual PD (-0.89 and -0.42 mm) and clinical attachment level (CAL) (-1.32 and -0.69 mm). While subgroup differences were observed, notably with EMD, high heterogeneity was present for CAL and PD, and evidence of certainty ranged from low to very low.
conclusionAdjunctive biologics improve clinical outcomes in suprabony periodontal defects; however, rigorous standardised trials are needed for reaching firm conclusions.
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