Evidence map›Paper›PMID 41535132›Full record

ArticleBiosensors & bioelectronics2026

Programmable PNA-nanoparticle hybrids as nanoscale recognition architectures for amplification-free nucleic acid recognition.

Satheesh Natarajan, David Skrodzki, Neela H Yennawar, John Gershenson, Dipanjan Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Satheesh NatarajanDepartment of Nuclear Engineering, Pennsylvania State University, University Park, PA, 16802, United States; Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, United States.
David SkrodzkiDepartment of Materials Science and Engineering, Pennsylvania State University, University Park, PA, 16802, United States.
Neela H YennawarHuck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, United States.
John GershensonHumanitarian Engineering and Social Entrepreneurship Program (HESE), The Pennsylvania State University, University Park, PA, 16802, United States.
Dipanjan PanDepartment of Nuclear Engineering, Pennsylvania State University, University Park, PA, 16802, United States; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, 16802, United States; Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA, 16802, United States; Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, United States; Department of Chemistry, Pennsylvania State University, University Park, PA, 16802, United States. Electronic address: dipanjan@psu.edu.

Funding

An integrated multiplexed diagnostic assay targeting fusion lipoproteins and cardiolipin for detection of treponemal and nontreponemal antibodies in syphilis patientsR01AI185115 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI Dipanjan Pan, Casey N Pinto · 2025 to 2026
$1.4M
Preclinical Evaluation of a Peptide-amphiphile Derived Toroidal Oxygen CarrierR01HL173540 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI Narayana Aluru, Paul Werner Buehler · 2025 to 2026
$1.4M
TA Instruments Low Volume AutoAffinity ITCS10OD025145 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2018 to 2018
$247k
NHLBI NIH HHS R01 HL173540NIAID NIH HHS R01 AI185115NIH HHS S10 OD025145
6 · The paper itself

Abstract

Rapid, field-deployable nucleic acid diagnostics require robust recognition elements and simple signal transduction. We present a programmable peptide nucleic acid-gold nanoparticle (PNA-AuNP) platform for amplification-free detection of Schistosoma spp. DNA. Thiolated PNAs were conjugated to citrate-stabilized AuNPs, forming a nanointerface that translates sequence-specific hybridization into a plasmonic colorimetric signal. Structural and thermodynamic validation confirmed duplex integrity: X-ray photoelectron spectroscopy revealed N 1s (+0.4 eV) and O 1s carbonyl (-0.2 eV) shifts, while FTIR showed amide I/II changes and new sugar-phosphate bands (921-1045 cm

Indexed as

Biosensing TechniquesDNAMetal NanoparticlesPeptide Nucleic AcidsSchistosomiasisAnimalsColorimetryGoldLimit of DetectionNucleic Acid HybridizationRapid Diagnostic TestsDNAGoldPeptide Nucleic AcidsFGSGold nanoparticleNanohybridsNano-LFAPeptide nucleic acid

Identifiers

PMID41535132
PMCPMC13445449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.