Evidence map›Paper›PMID 41535026›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Treat-and-repair Strategy for Atrial Septal Defect with Eisenmenger Syndrome due to Pulmonary Arterial Hypertension.

Muneyuki Kadota, Shusuke Yagi, Satoshi Akagi, Shingo Kasahara, Issei Yagi, Shingo Hashimoto, Yoshihito Saijo, Yutaka Kawabata, Tomonori Takahashi, Tomomi Matsuura and 5 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Muneyuki KadotaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Shusuke YagiDepartment of Community and Family Medicine/General Medicine, Tokushima University Graduate School of Biomedical Sciences, Japan.
Satoshi AkagiDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Shingo KasaharaDepartment of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
Issei YagiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Shingo HashimotoHashimoto Clinic, Japan.
Yoshihito SaijoDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Yutaka KawabataDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Tomonori TakahashiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Tomomi MatsuuraDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Takayuki IseDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Koji YamaguchiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Hirotsugu YamadaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Takeshi SoekiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.
Masataka SataDepartment of Cardiovascular Medicine, Tokushima University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 53-year-old man with Eisenmenger syndrome (ES), caused by a large secundum atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH), showed a marked hemodynamic improvement following an escalation of PAH-specific therapy. Surgical ASD closure using a fenestrated patch was successfully performed after a significant reduction in both the patient's pulmonary pressure and vascular resistance. This case highlights the potential utility of the "treat-and-repair" strategy in patients with ES and severe PAH, who exhibit a favorable response to medical therapy, resulting in both a symptomatic and hemodynamic improvement.

Indexed as

Eisenmenger ComplexHeart Septal Defects, AtrialHypertension, PulmonaryPulmonary Arterial HypertensionAntihypertensive AgentsHemodynamicsHumansMaleMiddle AgedTreatment OutcomeAntihypertensive Agentsatrial septal defectpulmonary arterial hypertensiontreat-and-repair

Identifiers

PMID41535026
PMCPMC13627608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.