Evidence map›Paper›PMID 41535024›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus.

Shintaro Yasui, Keisuke Nishimura, Yukina Tanimoto, Michio Mugitani, Tenyu Sugano, Marianne Linley Sy-Janairo, Daisuke Watanabe, Rina Sakai, Hirotaka Yamada, Jun Saegusa

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shintaro YasuiDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.
Keisuke NishimuraDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.
Yukina TanimotoDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.
Michio MugitaniDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.
Tenyu SuganoDepartment of Diagnostic Pathology, Kobe University Hospital, Japan.
Marianne Linley Sy-JanairoDepartment of Gastroenterology, Kobe University Graduate School of Medicine, Japan.
Daisuke WatanabeDepartment of Gastroenterology, Kobe University Graduate School of Medicine, Japan.
Rina SakaiDepartment of Medical Oncology/Hematology, Kobe University Hospital, Japan.
Hirotaka YamadaDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.
Jun SaegusaDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-losing enteropathy (PLE) is a rare complication of systemic lupus erythematosus (SLE). A 38-year-old woman with well-controlled SLE developed abdominal pain, lower-extremity edema, anemia, and hypoalbuminemia. The patient was then diagnosed with PLE. Despite treatment with glucocorticoids and cyclophosphamide, persistent hypoalbuminemia was observed. A biopsy was performed using double-balloon enteroscopy due to small bowel lesions, which confirmed the diagnosis of diffuse large B-cell lymphoma. To the best of our knowledge, this is the first reported case of diffuse large B-cell lymphoma mimicking PLE associated with SLE. The possibility of malignant lymphoma should be considered in cases of treatment-resistant PLEs associated with SLE.

Indexed as

Lupus Erythematosus, SystemicLymphoma, Large B-Cell, DiffuseProtein-Losing EnteropathiesAdultCyclophosphamideFemaleGlucocorticoidsHumansCyclophosphamideGlucocorticoidsdiffuse large B-cell lymphomaprotein-losing enteropathysystemic lupus erythematosus

Identifiers

PMID41535024
PMCPMC13561552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.