Evidence map›Paper›PMID 41534952›Full record

SynthesisBMJ health & care informatics2026

Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials.

Wilson Kin Chung Leung, Simon Ching Lam, Bobo Ching Lam Chan, Janice Ngar Lam Chow, Yvonne Yuet Ying Wong, Fowie Ng, Calvin Chi Kong Yip, Alex Chi Keung Chan

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMJ health & care informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wilson Kin Chung LeungSchool of Nursing, Tung Wah College, Hong Kong SAR, People's Republic of China.ORCID http://orcid.org/0000-0002-6196-4984
Simon Ching LamSchool of Nursing, Tung Wah College, Hong Kong SAR, People's Republic of China simonlam@twc.edu.hk simlc@alumni.cuhk.net.ORCID http://orcid.org/0000-0002-2982-9192
Bobo Ching Lam ChanSchool of Nursing, Tung Wah College, Hong Kong SAR, People's Republic of China.
Janice Ngar Lam ChowSchool of Nursing, Tung Wah College, Hong Kong SAR, People's Republic of China.
Yvonne Yuet Ying WongSchool of Management, Tung Wah College, Hong Kong SAR, People's Republic of China.
Fowie NgTranslational Research Centre for Digital Mental Health, Tung Wah College, Hong Kong SAR, People's Republic of China.
Calvin Chi Kong YipTranslational Research Centre for Digital Mental Health, Tung Wah College, Hong Kong SAR, People's Republic of China.
Alex Chi Keung ChanTranslational Research Centre for Digital Mental Health, Tung Wah College, Hong Kong SAR, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesChatbot-delivered treatments offer tremendous mental health benefits. This systematic review aimed at examining the effectiveness of using chatbots for improving mental health among people in Asia.

methodsRandomised controlled trials (RCTs) on standalone chatbot interventions targeting mental health conditions, ranging from mental well-being to clinically relevant mental health symptoms (eg, depression, anxiety, stress, affect, distress, insomnia and psychological well-being), were included. Four electronic databases (PubMed, CINAHL, PsycINFO and Medline) were searched until 11 December 2024.

resultsA total of eight RCTs (n=921) were included. Our meta-analysis results by random-effects models showed that chatbot interventions reduced the severity of depressive symptoms by 0.46 (95% CI -0.76 to -0.16, p=0.002, I DISCUSSION AND

conclusionChatbot-assisted therapy is a clinically beneficial and safe modality for treating depressive symptoms in the Asian context. PROSPERO REGISTRATION NUMBER: CRD42024546316.

Indexed as

Mental DisordersMental HealthAsiaDepressionGenerative Artificial IntelligenceHumansRandomized Controlled Trials as TopicHealth Services ResearchInformatics

Identifiers

PMID41534952
PMCPMC12815185

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.