Evidence map›Paper›PMID 41534911›Full record

ArticleNMR in biomedicine2026

Detection Accuracy of Ischemia and Neuroinflammation in Traumatic Brain Injury in Rats Using Amide Proton Transfer-Weighted MRI.

Yunfan Zou, Yinfeng Dong, Jieru Wan, Jianhua Lu, Shanshan Jiang, Raymond C Koehler, Jinyuan Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunfan ZouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Yinfeng DongDepartment of Anesthesiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jieru WanDepartment of Anesthesiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jianhua LuDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shanshan JiangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Raymond C KoehlerDepartment of Anesthesiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jinyuan ZhouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6684-7920

Funding

Developing Protein-based MRI Biomarkers for Alzheimer's DiseaseR01AG069179 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2020 to 2024
$3.3M
Development of Novel Functional Markers for TBI Using Molecular MRIUH3NS106937 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, ZHOU, JINYUAN · 2020 to 2022
$1.3M
Development of Novel Functional Markers for TBI Using Molecular MRIUG3NS106937 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, ZHOU, JINYUAN · 2018 to 2019
$859k
NIA NIH HHS R01 AG069179NIH HHS R01AG069179NIH HHS UH3NS106937NINDS NIH HHS UG3 NS106937NINDS NIH HHS UH3 NS106937Vivian L. Smith Foundation
6 · The paper itself

Abstract

Ischemia and neuroinflammation are two key secondary injury events following traumatic brain injuries (TBIs), but they are difficult to assess in vivo. Early detection of these secondary injuries post-TBI allows for precise severity assessment and enables timely, targeted interventions to reduce adverse outcomes. This study aimed to quantify the diagnostic accuracy of amide proton transfer-weighted (APTw) imaging to detect these two post-TBI endophenotypes. Controlled cortical impact (CCI) at depths of 1 mm (mild), 3 mm (moderate), and 5 mm (severe) was induced in 55 adult rats (28 males, 27 females), followed by 4.7 T MRI scanning (at 1 h, 1, 3, 7, 14, and 28 days). T

Indexed as

AmidesBrain Injuries, TraumaticBrain IschemiaMagnetic Resonance ImagingNeuroinflammatory DiseasesProtonsAnimalsFemaleMaleRatsRats, Sprague-DawleyAmidesProtonsamide proton transfer‐weighted MRIischemianeuroinflammationsecondary injurytraumatic brain injury

Identifiers

PMID41534911
PMCPMC13129811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.