ArticleJournal of advanced research2026
Bio-inspired supramolecular hydrogel inhibits ferroptosis to accelerate diabetic wound healing.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Iron, Copper, and Zinc Dyshomeostasis in Cardiovascular and Cerebrovascular Diseases: Redox Mechanisms, Evidence Levels, and Translational Prospects.International journal of molecular sciences · 2026Review
- Integrated OAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autophagy-Ferroptosis Interplay Network: Redefining Therapeutic Paradigms for Diabetic Wound Healing.Journal of inflammation research · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFerroptosis significantly compromises diabetic wound healing and represents a promising therapeutic target for clinical intervention. Baicalein (Bai), a natural flavonoid, has been considered to own ferroptosis-regulating properties, while the underlying mechanisms remain understood.
objectivesThe study aims to investigate potential mechanisms by which Bai inhibits ferroptosis in endothelial cells and validate the therapeutic efficacy of Bai-loaded hydrogel on diabetic wounds.
methodsHigh-glucose-cultured human umbilical vein endothelial cells (HUVECs) were chosen to study Bai's molecular mechanisms inhibiting ferroptosis. Subsequently, a Bai@GA/Gel/Zn
resultsIn vitro experiments, HUVECs were observed to exhibit characteristic ferroptosis, which were induced by high-glucose (HG) microenvironment, leading to compromised cellular functions. Through the inhibition of ferroptosis in HUVECs, Bai effectively promoted cell growth, migration, and angiogenesis. Herein, we further reveal that Bai inhibits HG-induced ferroptosis by modulating the Keap1/NRF2/HIF-1α signaling axis. To optimize therapeutic delivery, Bai was encapsulated into supramolecular nanofibers self-assembled from glycyrrhizic acid (GA), followed by cross-linking with gelatin (Gel) and zinc ions (Zn
conclusionIn summary, our findings reveal the ferroptosis-inhibiting mechanism of Bai and develop a Bai@GA/Gel/Zn
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