ArticleTranslational vision science & technology2025
Xenogenic Corneal Lenticules (XENIA) - Biomechanical Characterization and Enzymatic Resistance Analysis.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology.Health care science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Decellularized and cross-linked porcine stromal tissue offers a new option for corneal tissue augmentation. The aim of this study is to characterize the biomechanical properties and enzymatic resistance of processed xenogenic porcine corneal lenticules (XENIA) and compare them to human/porcine specimens. Methods: Groups of XENIA, human, and porcine corneal lenticules were formed. The dimensions of all lenticules were 7.7 mm in diameter and 80 µm in thickness. Conformité Européenne (CE)-approved XENIA-lenticules were provided by the manufacturer and human/porcine lenticules were generated using a femtosecond laser from the anterior stroma of cadaver eyes. All specimens were analyzed by uniaxial stress-strain measurements (n = 6 per group) and the resulting elastic moduli were compared. To evaluate the enzymatic resistance, all lenticules (n = 5 per group) were treated with collagenase solution (c = 0.1 U/mL) over a 20-day period and the lenticule size was analyzed by photo-documentation. Results: XENIA-lenticules showed the highest elastic modulus, significantly higher than human and porcine lenticules. At 11% strain, the maximum difference occurred between XENIA and porcine lenticules, with XENIA-lenticules being 23.5-fold stiffer. In the human lenticule group, donor age correlated strongly with the elastic moduli of this group (rs = 0.941, P = 0.005). XENIA-lenticules showed the greatest resistance against enzymatic digestion. On average, human samples were completely digested after 11 ± 4 hours, porcine samples after 91 ± 60 hours, whereas XENIA-lenticules only showed a digested area of 19.2% ± 13.7% after 20 days. Conclusions: XENIA-lenticules are substantially stiffer (3.9-9.6-fold stiffer than human tissue and 9.0-23.5-fold stiffer than porcine tissue across 5% to 17% strain) and resistant to enzymatic digestion compared to human/porcine probes. Translational Relevance: XENIA-lenticules may help to overcome the lack of human corneal donor tissue and may offer new alternatives for corneal augmentation therapies, such as for corneal melting or keratoconus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.