ArticleTranslational vision science & technology2025
Association Between Chronic Pain and Risk of Glaucoma: A Prospective Cohort Study.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Association between Circulating Ketone Bodies and Primary Open-Angle Glaucoma and Related Ocular Parameters.Ophthalmology science · 2026Article
- Associations Between Circulating Polyunsaturated Fatty Acids and Photoreceptor Measurement.Translational vision science & technology · 2026Article
- Association between regular hypnotic use and age-related macular degeneration.Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Chronic pain is a prevalent condition. Despite overlapping pathophysiological mechanisms, the association between chronic pain and glaucoma remains unclear. This study aimed to investigate their association through a prospective cohort analysis using data from the UK Biobank. Methods: Chronic pain was assessed at baseline through questionnaire. The patterns analyzed included the number of chronic pain locations and different single-location chronic pain. Participants were followed up until glaucoma diagnosis, death, or censoring. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazard models, adjusted for covariates. Results: Compared to individuals without chronic pain, those with chronic pain in three or more locations were at a significantly higher risk of glaucoma, with HRs of 1.20 (95% CI, 1.10-1.30; P < 0.001) for pain in three locations and 1.34 (95% CI, 1.24-1.46; P < 0.001) for pain in four or more locations. However, chronic pain in one or two locations did not show a significant association with glaucoma, and no individual pain location was independently associated with glaucoma risk. Conclusions: This study highlighted the potential cumulative effect of chronic pain across multiple locations on glaucoma risk. Translational Relevance: These findings highlight the potential need for further investigation into glaucoma screening in populations with chronic pain in multiple locations.
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