Evidence map›Paper›PMID 41533802›Full record

ArticleScience advances2026

Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis.

Junhoe Kim, Farzad Jalali-Yazdi, Brian E Jones, Gary L Westbrook, Eric Gouaux

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junhoe KimVollum Institute, Oregon Health & Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0001-5866-9952
Farzad Jalali-YazdiVollum Institute, Oregon Health & Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0002-0291-3482
Brian E JonesVollum Institute, Oregon Health & Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0009-0003-1338-6520
Gary L WestbrookVollum Institute, Oregon Health & Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0002-8108-5223
Eric GouauxVollum Institute, Oregon Health & Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0002-8549-2360

Funding

Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
3D STRUCTURE/FUNCTION OF LIGAND GATED ION CHANNELSR01NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 1999 to 2024
$6.7M
3D Structure and Function of Ligand-Gated Ion ChannelsR37NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Gouaux · 2009 to 2026
$4.1M
High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
Molecular mechanisms of exercise-induced synaptic plasticity in the hippocampusR01NS117371 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI WESTBROOK, GARY L · 2020 to 2024
$1.8M
Elucidating the Structural Mechanism of NMDA Receptor Modulation by Cryo-Electron MicroscopyF32MH115595 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI JALALI-YAZDI, FARZAD · 2017 to 2020
$192k
NIGMS NIH HHS R24 GM154185NIH HHS S10 OD034224NIMH NIH HHS F32 MH115595NINDS NIH HHS R01 NS038631NINDS NIH HHS R01 NS117371NINDS NIH HHS R37 NS038631
6 · The paper itself

Abstract

Autoantibodies targeting synaptic membrane proteins are associated with autoimmune encephalitis manifested by seizures, psychosis, and memory dysfunction. Anti-

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesCryoelectron MicroscopyReceptors, N-Methyl-D-AspartateAnimalsBinding SitesDisease Models, AnimalEpitopesHumansImmunizationMiceNerve Tissue ProteinsProtein BindingAutoantibodiesEpitopesNerve Tissue ProteinsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41533802
PMCPMC12802853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.