Evidence map›Paper›PMID 41533771›Full record

ArticleeLife2026

Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity.

Anjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anjali BishtDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.ORCID https://orcid.org/0000-0001-5519-4664
Srikanth PippadpallyDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.ORCID https://orcid.org/0000-0002-0636-9891
Snehasis MajumderDepartment of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.
Athulya T GopiDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.
Abhijit DasDepartment of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.
Chandan SahiDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.
Mani RamaswamiTrinity College Institute of Neuroscience (TCIN), University of Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-7631-0468
Vimlesh KumarDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.ORCID https://orcid.org/0000-0003-2206-4905

Funding

Science and Engineering Research Board EMR/2016/004718Wellcome Trust
6 · The paper itself

Abstract

Tauopathies represent a major class of neurodegenerative disorders associated with intracellular aggregates of the microtubule-associated protein Tau. To identify molecular modulators of Tau toxicity, we used a genetic screen to identify protein chaperones whose RNAi-mediated knockdown could modulate hTau

Indexed as

Drosophila ProteinsMolecular Chaperonestau ProteinsAnimalsDrosophilaDrosophila melanogasterMicrotubulesDrosophila ProteinsMolecular Chaperonesprefoldintau ProteinschaperonesD. melanogasterlearning and memorymicrotubulesneurodegenerationneuroscienceprefoldintauopathy

Identifiers

PMID41533771
PMCPMC12803513

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.