Evidence map›Paper›PMID 41533537›Full record

ArticleeLife2026

Insights from aquaporin structures into drug-resistant sleeping sickness.

Modestas Matusevicius, Robin A Corey, Marcos Gragera, Keitaro Yamashita, Teresa Sprenger, Marzuq Ungogo, James N Blaza, Pablo Castro-Hartmann, Dimitri Y Chirgadze, Sundeep Chaitanya Vedithi and 13 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies.International journal for parasitology. Drugs and drug resistance · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Modestas Matusevicius *Department of Medicine, University of Cambridge, Victor Phillip Dahdaleh Building, Heart and Lung Research Institute, Cambridge, United Kingdom.
Robin A Corey *Department of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-1820-7993
Marcos Gragera *Instruct Image Processing Centre (I2PC), Unidad de Biocomputación, Centro Nacional de Biotecnología, Madrid, Spain.ORCID https://orcid.org/0000-0002-3097-1743
Keitaro Yamashita *MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Teresa Sprenger *Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Marzuq UngogoSchool of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
James N BlazaStructural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, The University of York, York, United Kingdom.ORCID https://orcid.org/0000-0001-5420-2116
Pablo Castro-HartmannMaterials and Structure Analysis, Thermofisher Scientific, Eindhoven, Netherlands.
Dimitri Y ChirgadzeDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-9942-0993
Sundeep Chaitanya VedithiDepartment of Medicine, University of Cambridge, Victor Phillip Dahdaleh Building, Heart and Lung Research Institute, Cambridge, United Kingdom.
Pavel AfanasyevETH Zurich, ScopeM, Cryo-EM Knowledge Hub, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-6353-6895
Roberto MeleroInstruct Image Processing Centre (I2PC), Unidad de Biocomputación, Centro Nacional de Biotecnología, Madrid, Spain.
Rangana WarshamanageMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Anastasiia GusachMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
José-Maria CarazoInstruct Image Processing Centre (I2PC), Unidad de Biocomputación, Centro Nacional de Biotecnología, Madrid, Spain.ORCID https://orcid.org/0000-0003-0788-8447
Mark CarringtonDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-6435-7266
Tom BlundellDepartment of Medicine, University of Cambridge, Victor Phillip Dahdaleh Building, Heart and Lung Research Institute, Cambridge, United Kingdom.
Garib N MurshudovMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Phillip J StansfeldSchool of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, United Kingdom.
Mark S P SansomDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-6360-7959
Harry P De KoningSchool of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0002-9963-1827
Christopher G TateMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-2008-9183
Simone WeyandDepartment of Medicine, University of Cambridge, Victor Phillip Dahdaleh Building, Heart and Lung Research Institute, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-7965-0895

Funding

Biotechnology and Biological Sciences Research Council Impact Accelerator Award BB/S506734/1Gates Cambridge Trust Vice-Chancellor's AwardIsaac Newton Trust 15.40(a)Medical Research Council G0701258Medical Research Council MRC-DTP PhD fellowshipMedical Research Council U105197215Wellcome Trust 10.35802/101234Wellcome Trust 10.35802/208361Wellcome Trust 10.35802/217138Wellcome Trust 208398/Z/17/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aquaporin 2Drug ResistanceTrypanocidal AgentsTrypanosoma brucei bruceiBinding SitesCryoelectron MicroscopyGlycerolHumansMelarsoprolMolecular Dynamics SimulationMutationPentamidineProtein BindingProtein ConformationTrypanosomiasis, AfricanAquaporin 2GlycerolMelarsoprolPentamidineTrypanocidal Agentsaquaporincryo-EMmolecular biophysicsnonestructural biologystructure

Identifiers

PMID41533537
PMCPMC12803511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.