Evidence map›Paper›PMID 41533517›Full record

ArticleCell reports2026

Surround motion modulates the encoding properties of primate retinal ganglion cells.

Todd R Appleby, Fred Rieke, Michael B Manookin

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Todd R ApplebyNeuroscience Graduate Program, University of Washington, Seattle, WA, USA; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA; Department of Ophthalmology, University of Washington, Seattle, WA, USA; Vision Science Center, University of Washington, Seattle, WA, USA.
Fred RiekeDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA; Vision Science Center, University of Washington, Seattle, WA, USA.
Michael B ManookinDepartment of Ophthalmology, University of Washington, Seattle, WA, USA; Vision Science Center, University of Washington, Seattle, WA, USA. Electronic address: manookin@uw.edu.

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI Jay Neitz · 1985 to 2026
$23.5M
Unique physiological properties of novel ganglion cell types in primate retinaR01EY029247 · NEI · STANFORD UNIVERSITY · PI EDUARDO CHICHILNISKY, Michael B Manookin · 2018 to 2026
$4.7M
Function, diversity, and circuitry of parallel retinal ganglion cell pathwaysR01EY027323 · NEI · UNIVERSITY OF WASHINGTON · PI Michael B Manookin · 2018 to 2026
$3.9M
Mechanisms controlling retinal responses to natural stimuliR01EY028542 · NEI · UNIVERSITY OF WASHINGTON · PI FREDERICK M RIEKE · 2018 to 2026
$3.5M
Motion Processing by Interactions of Receptive Field Center and Surround in Primate Retinal Ganglion CellsF31EY032316 · NEI · UNIVERSITY OF WASHINGTON · PI APPLEBY, TODD · 2021 to 2023
$126k
NEI NIH HHS F31 EY032316NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY027323NEI NIH HHS R01 EY028542NEI NIH HHS R01 EY029247
6 · The paper itself

Abstract

Antagonistic interactions between center and surround regions of the receptive field are widely observed across sensory systems. In the early visual system, these interactions contribute to important computations such as edge detection. However, less is known about how center-surround interactions depend on the spatiotemporal properties of the visual input. Here, we show that surround motion strongly modulates the response properties of two understudied primate ganglion cell types. Broad thorny cell responses are strongest when motion in the center and surround is uncorrelated, similar to object-motion-sensitive cells found in other species. A different pattern is observed in On smooth monostratified cells: surround activation is suppressive for static stimuli and facilitatory for motion. These effects of surround activation diverge significantly from classical center-surround models and more closely resemble how surround motion affects responses in primate visual cortex.

Indexed as

Motion PerceptionRetinal Ganglion CellsAnimalsMotionPhotic StimulationVisual CortexCP: cell biologyCP: neurosciencemotion detectionneural facilitationobject vs. background motionprimate retinareceptive field

Identifiers

PMID41533517
PMCPMC12950331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.