Evidence map›Paper›PMID 41533514›Full record

ArticleCell reports2026

Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses.

Zhaoxu Chen, Zikeng Huang, William S Kim, Rahul Debnath, Kawintip Prasongyuenyong, Brett P DerGarabedian, Thao Do, MacKenzie A Moore-Kosslow, Jonathan M Korostoff, Chider Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhaoxu ChenDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zikeng HuangDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
William S KimDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rahul DebnathDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Paramedical Sciences, Assam down town University, Guwahati, Assam, India.
Kawintip PrasongyuenyongDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brett P DerGarabedianDepartment of Emergency Medicine, Cooper University Hospital, Camden, NJ, USA.
Thao DoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
MacKenzie A Moore-KosslowDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jonathan M KorostoffDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chider ChenDepartment of Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Innovation and Precision Dentistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yongwon ChoiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kang I KoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Innovation and Precision Dentistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: gank@upenn.edu.

Funding

Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Wound healing mechanisms by distinct oral fibroblast populationR01DE030415 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KO, KANG I · 2021 to 2025
$1.9M
NIAMS NIH HHS P30 AR069589NIDCR NIH HHS R01 DE030415
6 · The paper itself

Abstract

Fibroblasts are abundant structural cells with an emerging immune-sentinel role in the wound healing process, though its functional significance remains incompletely explored. By utilizing an oral injury model that heals rapidly, we identify murine PI16

Indexed as

FibroblastsMouth MucosaNeovascularization, PhysiologicT-Lymphocytes, RegulatoryWound HealingAnimalsHumansInflammationInterleukin-33Macrophage Migration-Inhibitory FactorsMiceMice, Inbred C57BLTransforming Growth Factor beta1Interleukin-33Macrophage Migration-Inhibitory FactorsTransforming Growth Factor beta1alarminangiogenesisCP: Immunologyfibroblastimmunomodulationinflammationinterleukin-33oral mucosaregenerationregulatory T cellswound healing

Identifiers

PMID41533514
PMCPMC12955373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.