Evidence map›Paper›PMID 41533484›Full record

ArticleChemistry, an Asian journal2026

Construction of the Pentacyclic Core of Yohimbine Alkaloids: A Chemoenzymatic Approach.

Luyao Wu, Zuming Lin, Lili Zhu, Sha-Hua Huang, Ran Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luyao WuFaculty of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, P.R. China.
Zuming LinFaculty of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, P.R. China.
Lili ZhuState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China.
Sha-Hua HuangFaculty of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, P.R. China.
Ran HongState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China.ORCID 0000-0002-7602-539X

Funding

National Natural Science Foundation of China 22271194National Natural Science Foundation of China U24A20484
6 · The paper itself

Abstract

An enantiodivergent route was devised for accessing the two enantiomers of indolo[2,3-a]quinolizidine, which serve as a platform for the synthesis of Corynanthe alkaloids with dimorphic configurations at the C3 position. The cascade process, involving dipolar cycloaddition, N-O bond cleavage, and cyclization, minimizes the need for functional group elaboration. Subsequent alkylation, allylation, and ring-closing metathesis smoothly constructed the pentacyclic ring system embedded in yohimbine alkaloids. The inherent simplicity and efficiency of enzymatic kinetic resolution prove valuable for diverse structural derivatives.

Indexed as

AlkaloidsYohimbineAlkylationCyclizationCycloaddition ReactionMolecular StructureStereoisomerismAlkaloidsYohimbinechemoenzymatic synthesisCorynanthe alkaloidsdipolar cycloadditionkinetic resolutionring‐closing metathesis

Identifiers

PMID41533484
PMCPMC13394362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.