Evidence map›Paper›PMID 41533455›Full record

ArticleeLife2026

The RNA-binding protein HuR modulates the expression of the disease-linked

Feroz Akhtar, Joselin Hernandez Ruiz, Ya-Guang Liu, Roy G Resendez, Denis Feliers, Liza D Morales, Alvaro Diaz-Badillo, Donna M Lehman, Rector Arya, Juan Carlos Lopez Alvarenga and 3 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Feroz AkhtarDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.ORCID https://orcid.org/0009-0009-1381-3856
Joselin Hernandez RuizUtah Center for Genetic Discovery, Department of Human Genetics, University of Utah, Salt Lake City, United States.
Ya-Guang LiuDepartment of Pathology, School of Medicine, University of Texas Health San Antonio, San Antonio, United States.
Roy G ResendezDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.
Denis FeliersDepartment of Medicine, School of Medicine, University of Texas Health San Antonio, San Antonio, United States.
Liza D MoralesSouth Texas Diabetes and Obesity Institute, Department of Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, United States.ORCID https://orcid.org/0000-0003-1056-9121
Alvaro Diaz-BadilloDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.
Donna M LehmanDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.
Rector AryaDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.
Juan Carlos Lopez AlvarengaDepartment of Population Health and Biostatistics, School of Medicine, University of Texas Rio Grande Valley, Harlingen, United States.
John BlangeroSouth Texas Diabetes and Obesity Institute, Department of Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, United States.
Ravindranath DuggiralaDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.
Srinivas MummidiDepartment of Health and Behavioral Sciences, Texas A&M University-San Antonio, San Antonio, United States.ORCID https://orcid.org/0000-0002-4068-6380

Funding

Impact of disease associated noncoding polymorphisms on post-transcriptional gene regulationR01AI119131 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI MUMMIDI, SRINIVAS · 2016 to 2019
$1.5M
National Institute of Allergy and Infectious Diseases 5R01AI119131NIAID NIH HHS R01 AI119131
6 · The paper itself

Abstract

CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles: A>G; G is the risk allele) polymorphism in the

Indexed as

Chemokine CCL2ELAV-Like Protein 1Gene Expression RegulationHaplotypesPolymorphism, Single Nucleotide3' Untranslated RegionsAllelesHumansLinkage DisequilibriumRNA, MessengerRNA Stability3' Untranslated RegionsCCL2 protein, humanChemokine CCL2ELAVL1 protein, humanELAV-Like Protein 1RNA, Messengerallelic expression imbalanceCCL2geneticsgenetic variationgenomicshumanHuRmRNA stabilityRNA-binding proteins

Identifiers

PMID41533455
PMCPMC12803514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.