Evidence map›Paper›PMID 41533441›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Elizabeth A Turcotte, Kyungsub Kim, Kevin D Eislmayr, Lisa Goers, Patrick S Mitchell, Cammie F Lesser, Russell E Vance

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

7 authors.

Elizabeth A TurcotteDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-0165-7173
Kyungsub KimDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-2897-0220
Kevin D EislmayrDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Lisa GoersDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1585-8726
Patrick S MitchellDepartment of Microbiology, University of Washington, Seattle, WA 98109.
Cammie F LesserDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1702-6333
Russell E VanceDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-6686-3912

Funding

Functional and Structural Dissection of Inflammasome ActivationR37AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUSSELL E VANCE · 2018 to 2026
$3.8M
Specificity and in vivo function of the Naip/Nlrc4 inflammasomesR01AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2008 to 2017
$3.6M
Shigella mediated regulation of epithelial cell inflammasomesR01AI169795 · NIAID · TUFTS UNIVERSITY BOSTON · PI CAMMIE LESSER · 2023 to 2026
$3.0M
Dissection of Shigella pathogenesis in vivo using a new oral infection mouse modelR01AI155634 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2020 to 2024
$2.2M
HHS | NIH (NIH) AI075039HHS | NIH (NIH) AI155634HHS | NIH (NIH) AI169795NIAID NIH HHS R01 AI075039NIAID NIH HHS R01 AI155634NIAID NIH HHS R01 AI169795NIAID NIH HHS R37 AI075039NSF | NSF Graduate Research Fellowship Program (GRFP) DGE 1752814
6 · The paper itself

Abstract

The NAIP-NLRC4 inflammasome senses pathogenic bacteria by recognizing the cytosolic presence of bacterial proteins such as flagellin and type III secretion system (T3SS) subunits. In mice, the NAIP-NLRC4 inflammasome provides robust protection against bacterial pathogens that infect intestinal epithelial cells, including the gastrointestinal pathogen

Indexed as

Bacterial ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsInflammasomesNeuronal Apoptosis-Inhibitory Proteinp38 Mitogen-Activated Protein KinasesShigella flexneriAnimalsDysentery, BacillaryHumansInnate Immunity RecognitionMiceTHP-1 CellsBacterial ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsInflammasomesNAIP protein, humanNeuronal Apoptosis-Inhibitory ProteinNLRC4 protein, humanp38 Mitogen-Activated Protein KinaseseffectorinflammasomesShigella

Identifiers

PMID41533441
PMCPMC12818434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.