Evidence map›Paper›PMID 41533366›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Vascular endothelial function is preserved in women with a history of preeclampsia currently receiving antidepressant pharmacotherapy.

Ruda Lee, Jody L Greaney, Mark K Santillan, Gary L Pierce, Anna E Stanhewicz

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruda LeeDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-4886-5903
Jody L GreaneyDepartment of Health Behavior and Nutrition Sciences, University of Delaware, Newark, Delaware, United States.ORCID 0000-0002-9855-3978
Mark K SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-3991-8017
Gary L PierceDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-7499-080X
Anna E StanhewiczDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-3941-3879

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
American Heart Association (AHA) 937990American Heart Association-American Stroke Association 937990HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002537NCATS NIH HHS UL1 TR002537
6 · The paper itself

Abstract

Women with a history of preeclampsia (hxPE) have an elevated risk of cardiovascular disease, likely in part from reduced endothelial function. Preeclampsia is also associated with increased risk of depression. Although evidence indicates that antidepressant pharmacotherapy may have vasculoprotective effects, it is unclear whether it preserves endothelial function in women with hxPE. We hypothesized that antidepressant-treated women with hxPE would have preserved endothelial function compared with unmedicated women with hxPE. Ten women with hxPE currently treated with an antidepressant (hxPE + AD), 10 not treated (hxPE - AD), and 10 unmedicated women with a history of uncomplicated pregnancy (HC) participated. Macrovascular endothelial function was measured via brachial artery flow-mediated dilation (FMD). Microvascular endothelial function and the nitric oxide (NO) component were assessed via cutaneous vascular conductance (CVC; %max) responses to graded infusions of acetylcholine (10

Indexed as

Antidepressive AgentsBrachial ArteryEndothelium, VascularPre-EclampsiaVasodilationAcetylcholineAdultFemaleHumansMicrocirculationNG-Nitroarginine Methyl EsterNitric OxidePregnancyVasodilator AgentsYoung AdultAcetylcholineAntidepressive AgentsNG-Nitroarginine Methyl EsterNitric OxideVasodilator Agentsantidepressantendothelial functionnitric oxidepostpartum depressionpreeclampsia

Identifiers

PMID41533366
PMCPMC12914748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.