ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026
Altered p53 Gene Expression in Coronary Artery Disease Patients with Dyslipidemia: Implications for Atherogenesis.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA concerning increase in coronary artery disease (CAD) among younger Indians calls attention to genetic biomarkers that indicate early vascular stress. The tumor suppressor gene p53, known primarily for its oncogenic role, also modulates vascular apoptosis and inflammation. However, its link with metabolic and nitrosative stress in CAD remains underexplored.
aimTo determine the potential of p53 as an integrated biomarker and to analyze the connection between p53 gene expression, lipid abnormalities, inflammatory (IL-6) and nitrosative (3-nitrotyrosine) markers in CAD.
methodsIn this case-control study, 90 CAD patients and 90 age-matched healthy controls (18-50 years old) participated. Enzymatic techniques were used to evaluate lipid profile parameters, RT-PCR was used to detect p53 gene expression (2^
resultsCAD subjects showed higher total cholesterol, triglycerides, LDL-C, IL-6,and 3-NT, and lower HDL-C compared with controls (all p < 0.01). p53 was up-regulated 1.6-fold in CAD and correlated positively with 3-NT (r = 0.709, p < 0.001) and IL-6 (r = 0.513, p < 0.01).
conclusionThis is the first Indian case-control study to integrate p53 gene expression with lipid, inflammatory, and nitrosative markers in relatively young CAD patients, offering a novel molecular perspective on early atherogenesis.
Indexed as
Identifiers
41533273What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.