Evidence map›Paper›PMID 41533257›Full record

Observational studyJapanese journal of ophthalmology2026

Ten-year changes in risk factors for requiring treatment of retinopathy of prematurity in extremely low birth weight infants: a multicenter study in Tokyo.

Takako Tachikawa, Ken Masunaga, Mariko Kiyota, Reiko Kushima, Sachiko Nishina, Tetsuya Isayama, Eiichiro Noda, Kaoru Okazaki, Toshinari Funaki, Atsushi Nakao and 12 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Takako TachikawaDepartment of Ophthalmology, Tokyo Metropolitan Ohtsuka Hospital, Minami-Ohtsuka 2-8-1, Toshima-ku, Tokyo, Japan. takako_tachikawa@tmhp.jp.
Ken MasunagaDepartment of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Minami-Ohtsuka 2-8-1, Toshima-ku, Tokyo, Japan.
Mariko KiyotaDepartment of Ophthalmology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Reiko KushimaDepartment of Neonatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Sachiko NishinaDivision of Ophthalmology, National Center for Child Health and Development, Tokyo, Japan.
Tetsuya IsayamaDivision of Neonatology, National Center for Child Health and Development, Tokyo, Japan.
Eiichiro NodaDepartment of Ophthalmology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Kaoru OkazakiDepartment of Neonatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Toshinari FunakiDepartment of Ophthalmology, Japanese Red Cross Medical Center, Tokyo, Japan.
Atsushi NakaoDepartment of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan.
Tadashi MatsumotoDepartment of Ophthalmology, Toho University School of Medicine, Oomori, Tokyo, Japan.
Hiroko AraiDepartment of Neonatology, Toho University School of Medicine, Tokyo, Japan.
Yuta SaitoDepartment of Ophthalmology, Showa Medical University School of Medicine, Tokyo, Japan.
Tokuo MiyazawaDepartment of Pediatrics, Showa Medical University School of Medicine, Tokyo, Japan.
Takashi NegishiDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Hiromichi ShojiDepartment of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Taku ToyamaDepartment of Ophthalmology, The University of Tokyo, Graduate School of Medicine and Faculty of Medicine, Tokyo, Japan.
Riki NishimuraDepartment of Neonatology, The University of Tokyo, Graduate School of Medicine and Faculty of Medicine, Tokyo, Japan.
Ritsuko UenoDepartment of Ophthalmology, Tokyo Metropolitan Ohtsuka Hospital, Minami-Ohtsuka 2-8-1, Toshima-ku, Tokyo, Japan.
Funato SatoUniversity Research Promotion Center, Tokyo Metropolitan Hospital Organization, Tokyo, Japan.
Yoshihiko MorikawaDepartment of Neonatal Intensive Care, Perinatal Medical Center, Jichi Medical University Hospital, Tochigi, Japan.
Neonatal Research Network of Japan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate 10-year changes in risk factors associated with treatment required for retinopathy of prematurity (ROP) in extremely low birth weight infants. STUDY

designRetrospective cohort study.

methodsData for extremely low birth weight infants born in 2011 (Group 1) and those born in 2020-2021 (Group 2) were extracted from the Neonatal Research Network of Japan, with a total of 564 cases. The frequency of ROP treatment-related risk factors and results of multivariate analyses were compared between the two groups. Missing data in covariates were handled using multiple imputation.

resultsGroup 2 had a significantly lower birth weight (p=0.038), gestational age (p=0.037), and Apgar scores (p<0.001), than Group 1. The frequencies of resuscitation with intubation (p=0.030), oxygen therapy beyond 36 weeks' postmenstrual age (p<0.001), chronic lung disease (p=0.012), gastrointestinal perforation (p=0.030), and red blood cell transfusion (p=0.018) were higher in Group 2 than in Group 1. However, the incidence and treatment rate of ROP decreased over time. The multivariate analysis shows that mechanical ventilation for 60 days or more is a strong independent risk factor for ROP treatment in Group 1, but this effect disappeared in Group 2.

conclusionBirth weight and gestational age of extremely low birth weight infants born in Tokyo have decreased significantly compared with 10 years previously, and the severity of ROP has not increased. Advances in respiratory management may have contributed to reducing the risk of developing severe ROP.

Indexed as

Infant, Extremely Low Birth WeightRetinopathy of PrematurityBirth WeightFemaleFollow-Up StudiesGestational AgeHumansIncidenceInfant, NewbornMaleRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTokyoExtremely low birth weight (ELBW)Retinopathy of prematurity (ROP)Risk factorSurvival rate

Identifiers

PMID41533257

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.