Evidence map›Paper›PMID 41533253›Full record

ArticleDiscover oncology2026

Indigestible carbohydrates suppress colorectal cancer through IRF6/TRAF3/IFNα pathway.

Lin Tan, Yuqi He, Linhui Wu, Binbin Ding, Chao Zhang, Pingfei Tang, Liping Qin, Dajun Wu, Yunzhu Long

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin TanDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Yuqi HeDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Linhui WuDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Binbin DingDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Chao ZhangDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Pingfei TangDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Liping QinDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China.
Dajun WuDepartment of Gastroenterology Medical Center of Digestive Disease Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China. wudajun1975@163.com.
Yunzhu LongCancer Prevention Center Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, 116 Changjiangnan Road, Tianyuan District, Zhuzhou, 412007, Hunan, China. longyunzhu@csu.edu.cn.

Funding

Hunan Province Natural Science Foundation of China NO.2022JJ70085Hunan Province Natural Science Foundation of China NO.2023JJ50219Scientific Research Project of Hunan Provincial Health Commission NO.W20243154
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is one of most common cancers with high morbidity and mortality. Previous studies have indicated that people with higher dietary fiber intake, including non-digestible starch (NDCs), have a lower risk of CRC. The exact mechanism of NDCs in reducing CRC risk and processes remains unclear. MATERIALS AND

methodsIRF6, TRAF3 and IFNα expressions were detected in CRC samples, with subsequent analysis of the correlations between IRF6 and TRAF3 and between IRF6 and IFNα. The effects of sodium butyrate (NaB) on IRF6, TRAF3 and IFNα expression in CRC, cell proliferation, migration and EMT were confirmed in vitro. The interaction between IRF6 and TRAF3 were verified by WB and immunoprecipitation experiments. The effects of NDCs on tumor growth and IRF6 expression were confirmed in vivo.

resultsOur results showed that IRF6, TRAF3, IFNα expression in CRC was significantly lower than that in adjacent tissues, and IRF6 expression correlated with TRAF3 and IFNα positively. NaB and IRF6 could significantly inhibit the cell proliferation, migration and EMT of CRC cells and IRF6 could bind to TRAF3. NDCs could reduce the lesions of in situ CRC induced by inflammation, and IRF6 expression in colon tissue of mice in NDCs group was significantly increased.

conclusionOur study suggested that NDCs intake may regulate IFNα activation by up-regulating IRF6 to inhibit TRAF3 degradation to inhibit the proliferation and migration of tumor cells. Our study will provide theoretical basis and data support for reducing the risk of CRC through dietary regulation and exploring potential therapeutic targets.

Indexed as

Colorectal cancerIFNαIndigestible carbohydratesIRF6TRAF3

Identifiers

PMID41533253
PMCPMC12891285

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.