ReviewMolecular neurobiology2026
Mapping the Evolution of Brain Organoid Research: A Decade of Progress and Future Perspectives (2015-2025).
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Brain organoids have revolutionized neuroscience by providing unique in vitro models for studying human brain development and disease. This study presents a comprehensive bibliometric analysis of brain organoid research from 2015 to 2025, integrating VOSviewer and CiteSpace, while using Scimago Graphica to enhance the visualization. Our journal analysis reveals Stem Cell Reports and Cell Stem Cell as stable high-impact venues, with Stem Cell Reports and Nature Communications showing the fastest growth. Geographically, the USA and European nations maintain dominance in both productivity and citation impact. We systematically mapped the field's evolution across three phases: the technological germination period (2001-2014), rapid expansion from foundation to application (2015-2020), and recent developments including refinement and ethical considerations (2020-2025). Our analysis reveals key factors contributing to the field's recent cooling trend, including standardization challenges, diversification trends, and emerging ethical concerns. We identify major research hotspots such as vascularization and microenvironment optimization and also highlight critical milestones such as the development of fused organoid systems and vascularized models. This study not only provides a historical perspective on brain organoid research but also offers valuable insights for future directions, emphasizing the need for standardized protocols, enhanced international and multidisciplinary collaboration, and balanced ethical frameworks to sustain progress in this transformative field.
Indexed as
Identifiers
41533250What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.