ArticleBulletin of experimental biology and medicine2025
Growth-Stimulating Effect of Platelet Lysates Obtained with Low-Pulse Laser Radiation in Human Fibroblast Culture.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The growth-stimulating effect of platelet lysates obtained after exposure of platelet suspension to low-pulse laser radiation (LPLR) with λ = 470 nm (blue laser) and λ = 635 nm (red laser) was studied in a culture of human M-22 fibroblasts. LPLR-irradiated platelet suspension in plasma and plasma-free medium reduced the content of platelets with granules by 5-7% at λ = 470 nm and 25-27% at λ = 635 nm (p < 0.05). In presence of platelet lysates, the number of fibroblasts significantly increased by 1.3-1.4 times after 3 days of cultivation. In experiments with platelets in plasma-free medium, the samples previously irradiated at λ = 470 nm produced a lower growth-stimulating effect, than samples irradiated at λ = 635 nm and non-irradiated samples; for platelets irradiated in autologous plasma, no prominent differences were observed. Lysates of LPLR-irradiated platelets did not impair structural integrity of human fibroblasts in culture.
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