Evidence map›Paper›PMID 41533233›Full record

ArticleBulletin of experimental biology and medicine2025

Short-Term Simulated High-Altitude Hypoxia Enhances Na,K-ATPase Efficiency in Maintaining Rat Diaphragm Electrogenesis.

V V Kravtsova, A A Fedorova, V O Matytsin, D D Ganke, O V Vetrovoy, I I Krivoi

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

V V KravtsovaSt. Petersburg State University, St. Petersburg, Russia.
A A FedorovaSt. Petersburg State University, St. Petersburg, Russia.
V O MatytsinKirov Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
D D GankeSt. Petersburg State University, St. Petersburg, Russia.
O V VetrovoySt. Petersburg State University, St. Petersburg, Russia.
I I KrivoiSt. Petersburg State University, St. Petersburg, Russia. iikrivoi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Na,K-ATPase activity is critical for maintaining electrogenesis and skeletal muscle function. Isolated rat diaphragm muscles were studied after 3-h high-altitude hypobaric hypoxia (HAH, corresponds to an altitude of 6000 m) in a pressure chamber. LPO activation was observed over 24 h after HAH; no significant changes in other markers of oxidative stress and energy metabolism were detected. During this period, stable hyperpolarization of the sarcolemma developed due to increased electrogenic activity of the α2-Na,K-ATPase isoform, while the total muscle level of the α2-subunit protein remained unchanged. Our findings may have practical implications for developing measures to maintain skeletal muscle functions during high-altitude adaptation.

Indexed as

DiaphragmHypoxiaSodium-Potassium-Exchanging ATPaseAltitudeAnimalsMaleMembrane PotentialsMuscle, SkeletalOxidative StressRatsRats, WistarSarcolemmaSodium-Potassium-Exchanging ATPaseelectrogenic activityhigh-altitude hypoxiaNa,K-ATPaserat diaphragmresting membrane potential

Identifiers

PMID41533233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.