Trial reportClinical oral investigations2026
Immediate versus conventional loading in users of mandibular overdentures retained by narrow-diameter implants: results from a 5-year randomized clinical trial.
Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesThis randomized clinical trial (RCT) aimed to evaluate clinical, radiographic, functional, and patient-centered outcomes in users of mandibular two-implant overdentures (2-IMO) subjected to immediate loading (IL) and conventional loading (CL) protocols over a five-year follow-up period.
methodsTwenty participants were randomly allocated to the CL (n = 10) and IL (n = 10) groups. Clinical peri-implant health parameters, radiographic assessments of marginal bone loss (MBL) and posterior area index (PAI), functional outcomes through masticatory performance (MP), patient-reported outcomes using the Daily Impact on Daily Life (DIDL) questionnaire, and prosthetic maintenance events were evaluated at 1, 3, and 5 years post-treatment. Data were analyzed using multilevel mixed-effects linear regression models, and differences in prosthetic maintenance events over the 5-year follow-up were assessed using binary logistic regression, with the significance level set at 5%.
resultsAt the five-year follow-up, MBL and the masticatory domain scores were significantly lower in the IL group (p = 0.01; p = 0.03, respectively). No statistically significant differences between groups were observed for MP, PAI, or the remaining DIDL domains (p > 0.05). Intragroup comparisons revealed significant differences (p < 0.05) in peri-implant health, with a reduction observed in the IL group between the first and fifth years. A slight increase in MBL was noted in the CL group, while stability was maintained in the IL group. PAI demonstrated a progressive increase in both groups across all time points. For DIDL scores, the IL group exhibited a significant deterioration in all domains from the third year onward. Over the 5-year period, overall maintenance requirements were comparable between the CL and IL groups (136 vs. 159 events). Nylon O-ring replacement, matrix recapture, and prosthesis adjustments were the most frequent interventions. The IL group was significantly more likely to require nylon O-ring replacement (OR: 1.68; P = 0.03), while showing a markedly lower need for keratinized tissue removal (OR: 0.11; P = 0.04).
conclusionsUsers of 2-IMO subjected to immediate loading tend to report decreased satisfaction with treatment outcomes from the third year of function onward. CLINICAL RELEVANCE: The IL protocol resulted in better peri-implant health parameters, reduced marginal bone loss, and fewer prosthetic maintenance events at the final assessment, while masticatory performance and PAI outcomes were comparable between groups.
Indexed as
Identifiers
41533178What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.