Evidence map›Paper›PMID 41533055›Full record

ArticleCNS neuroscience & therapeutics2026

Acute Stress Attenuates Hepatic Ischemia-Reperfusion Injury via Hypothalamic CRH Neuron-Induced HPA Axis Activation.

Xiaoqi Lin, Dan Yang, Shuyang Wang, Baoshan Wang, Ling Zhu, Yanyu Zhou, Yifei Zhou, Song Zhang, Qionghui Zhan, Yingfu Jiao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoqi LinDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dan YangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuyang WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Baoshan WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7281-2169
Ling ZhuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanyu ZhouDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yifei ZhouDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Song ZhangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-7997-274X
Qionghui ZhanDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yingfu JiaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weifeng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liqun YangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-5801-7890
Po GaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-2860-3239

Funding

Fundamental Research Funds for the Central Universities 25X010202804National Key Research and Development Program of China: Special Project for Modernization of Traditional Chinese Medicine - Young Scientist Project 2025YFC3510700National Natural Science Foundation of China 82270916National Natural Science Foundation of China 82300725National Natural Science Foundation of China 82371478National Natural Science Foundation of China 82371517National Natural Science Foundation of China U23A20508Sanming Project of Medicine in Shenzhen SZSM202311003Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation 20DZ2254200
6 · The paper itself

Abstract

backgroundHepatic ischemia-reperfusion injury (HIRI) is a pathologic process commonly encountered during liver surgery, which seriously threatens patient prognosis. Currently, effective interventions or preventive measures are still lacking. Notably, patients with liver disease commonly experience brief acute stress prior to surgery; however, the impact of acute stress on HIRI remains unclear.

methodsA 30-min restraint stress was used to simulate acute restraint stress (ARS). Hematoxylin-eosin staining and ELISA were employed to assess HIRI. Immunofluorescence staining and electrophysiology were applied to evaluate neuronal activation. Chemogenetic manipulation was utilized to verify the role of corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) in ARS-mediated attenuation of HIRI.

resultsThe results showed that ARS significantly ameliorated liver injury, reduced the liver enzyme levels (ALT and AST), and down-regulated the inflammatory factors expression in HIRI mice. Furthermore, we found that ARS alleviated HIRI by activating the hypothalamic-pituitary-adrenal (HPA) axis to release corticosterone, rather than through the sympathetic nervous system. PVN

conclusionOur findings demonstrate that PVN

Indexed as

Corticotropin-Releasing HormoneHypothalamo-Hypophyseal SystemLiverNeuronsParaventricular Hypothalamic NucleusPituitary-Adrenal SystemReperfusion InjuryStress, PsychologicalAnimalsCorticosteroneMaleMiceMice, Inbred C57BLRestraint, PhysicalCorticosteroneCorticotropin-Releasing Hormoneacute stressCRH neuronshepatic ischemia–reperfusion injuryHPA axishypothalamic paraventricular nucleus

Identifiers

PMID41533055
PMCPMC12802567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.