Evidence map›Paper›PMID 41532979›Full record

Observational studyPediatrics international : official journal of the Japan Pediatric Society

Combining thiopurine with partial enteral nutrition promotes complete mucosal healing in pediatric Crohn's disease.

Emiri Kaji, Atsushi Yoden, Takahiro Namba, Satomi Nishimoto, Masano Otani, Takeru Okuhira, Keisuke Inoue, Tomoki Aomatsu, Daisuke Nishioka, Akira Ashida

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emiri KajiDepartment of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.ORCID https://orcid.org/0000-0002-2929-7085
Atsushi YodenDepartment of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Takahiro NambaDepartment of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Satomi NishimotoDepartment of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Masano OtaniDepartment of Pediatrics, Osaka Saiseikai Suita Hospital, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0002-5105-3503
Takeru OkuhiraOkuhira Nobinobi Children's Clinic, Mishima, Osaka, Japan.ORCID https://orcid.org/0000-0002-7707-293X
Keisuke InoueInoue Children's Clinic, Hirakata, Osaka, Japan.
Tomoki AomatsuAomatsu Pediatrics Clinic, Takatsuki, Osaka, Japan.
Daisuke NishiokaDepartment of Medical Statistics, Research & Development Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.ORCID https://orcid.org/0000-0002-3116-1195
Akira AshidaDepartment of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe combination of thiopurines and partial enteral nutrition (TP/PEN) is a common maintenance therapy for mild-to-moderate Crohn's disease (CD) in pediatric patients. However, no studies have investigated the efficacy of TP/PEN. This study aimed to evaluate the non-relapse and complete mucosal healing rates in pediatric CD patients following treatment with or without TP, in addition to PEN.

methodsThis retrospective observational study included 39 pediatric patients diagnosed with mild-to-moderate CD. Based on the proposed treatment, the patients were divided into the TP/PEN and PEN-only groups. The primary outcome was the relapse-free rate between the two groups. Relapse was defined as a pediatric Crohn's disease activity index (PCDAI) >12.5, Simple Endoscopic Score-CD (SES-CD) score >7, Lewis score > 135, and/or abnormal C-reactive protein levels (CRP > 0.15 mg/dL). The secondary outcome was complete mucosal healing (SES-CD score 0) at 12-24 months.

resultsAlthough the difference in non-relapse rate between the two groups was not statistically significant, complete mucosal healing rates were significantly higher in the TP/PEN group than in the PEN-only group. Complete mucosal healing at 12-24 months was achieved in 7/21 (33.3%) and 1/18 (5.5%) patients in the TP/PEN and PEN-only groups, respectively (p < 0.05).

conclusionNowadays, more treatment options are available, and TP/PEN remains a viable option for the treatment of mild-to-moderate CD in pediatric patients.

Indexed as

AzathioprineCrohn DiseaseEnteral NutritionImmunosuppressive AgentsIntestinal MucosaMercaptopurineWound HealingAdolescentChildCombined Modality TherapyFemaleHumansMaleRetrospective StudiesSeverity of Illness IndexTreatment OutcomeAzathioprineImmunosuppressive AgentsMercaptopurinemaintenance therapypartial enteral nutritionpediatric Crohn's diseasethiopurine

Identifiers

PMID41532979
PMCPMC12802816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.