Evidence map›Paper›PMID 41532961›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Intestinal Atresia in Finland: Maternal Risk Factors, Prevalence, Associated Anomalies and Survival.

Esko Tahkola, Arimatias Raitio, Ilkka Helenius, Johanna Syvänen, Teemu Kemppainen, Eliisa Löyttyniemi, Maarit K Leinonen, Mika Gissler, Topi Luoto, Mikko P Pakarinen

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Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Esko TahkolaDepartment of Pediatric Surgery, Kuopio University Hospital, University of Eastern Finland and University of Helsinki, Helsinki, Finland.ORCID 0009-0003-3216-2186
Arimatias RaitioDepartment of Pediatric Surgery and Orthopedics, University of Turku and Turku University Hospital, Turku, Finland.
Ilkka HeleniusDepartment of Orthopedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Johanna SyvänenDepartment of Pediatric Surgery and Orthopedics, University of Turku and Turku University Hospital, Turku, Finland.
Teemu KemppainenDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Maarit K LeinonenDepartment of Data and Analytics, Finnish Institute of Health and Welfare, Helsinki, Finland.
Mika GisslerDepartment of Data and Analytics, Finnish Institute of Health and Welfare, Helsinki, Finland.ORCID 0000-0001-8254-7525
Topi LuotoDepartment of Pediatric Surgery, Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
Mikko P PakarinenSection of Pediatric Surgery, Pediatric Liver and Gut Research Group, Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

Helsingin Yliopiston TiedesäätiöLastentautien TutkimussäätiöMedicinska Understödsföreningen Liv och HälsaPäivikki ja Sakari Sohlbergin SäätiöSigrid Juséliuksen Säätiöthe Finnish Paediatric Research Foundation
6 · The paper itself

Abstract

aimWe aimed to investigate prevalence, associated anomalies and survival of congenital intestinal atresia and to examine maternal risk factors for jejunoileal atresia (JIA).

methodsAll children born with, or pregnancies terminated because of, JIA or colonic atresia (CA) in Finland during 1987-2019 were identified from the Finnish Register of Congenital Malformations. Clinical information was obtained from national health registers. Maternal risk factors were assessed using all JIA cases from 2004 to 2017 (n = 101). For each case, five appropriately matched live-born controls were selected.

resultsWe identified 175 JIA and 48 CA cases. About half were isolated anomalies. Gastrointestinal anomalies were the most common associated defects (26% in JIA, 35% in CA), followed by cardiac anomalies in JIA (13%) and urinary tract anomalies in CA (19%). Survival was 88% in JIA and 94% in CA. Only two of 224 patients died directly due to intestinal atresia. Maternal insulin use (adjusted odds ratio [aOR] 8.4, 95% CI 1.4-51.0) and propionic acid derivatives (aOR 4.6, 95% CI 1.5-14.8) were associated with increased JIA risk.

conclusionAlthough associated anomalies were frequent, mortality in intestinal atresia remained low. Maternal insulin and propionic acid derivative use may meaningfully contribute to JIA risk. LEVEL OF EVIDENCE: IV.

Indexed as

Abnormalities, MultipleIntestinal AtresiaCase-Control StudiesFemaleFinlandHumansInfant, NewbornMalePregnancyPrevalenceRisk Factorscolonic atresiajejunoileal atresiamaternal risk factors

Identifiers

PMID41532961
PMCPMC13063365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.