ArticleJournal of cosmetic dermatology2026
Mastering Midface Rejuvenation: A Proposal for a New Three-Layer, Ultrasound-Guided Technique.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- A Case Series on a Layered Biomaterial Strategy for Midface Rejuvenation: Combining Collagen Stimulators and Hyaluronic Acid.Journal of cosmetic dermatology · 2026Article
- Mastering Midface Rejuvenation: A Proposal for a New Three-Layer, Ultrasound-Guided Technique.Journal of cosmetic dermatology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAging affects all facial layers: deep fat atrophy reduces midface projection, superficial fat changes alter facial contour, and dermal thinning compromises skin texture. Midface rejuvenation aims to restore malar projection, cheek volume, and youthful contours, thereby improving the nasolabial fold and suborbicular region. Conventional multilayer techniques address both deep and superficial fat compartments using fillers with distinct rheological properties, but often neglect skin quality and the advantages of ultrasound guidance. The approach we propose is grounded on three core principles: the comprehensive anatomical knowledge, the use of high-frequency ultrasound to ensure precise and safe injections, and the selection of hyaluronic acid fillers specifically tailored to each tissue plane-deep, superficial, and dermal. The aim of our work was to present our technique as a proof of concept for a three-layer, ultrasound-assisted technique, which enhances safety, precision, and aesthetic effectiveness, representing a significant advancement in modern facial rejuvenation.
methodsA three-layer, ultrasound-guided midface rejuvenation technique employs tailored hyaluronic acid fillers for each plane. Firm, high G' fillers target deep compartments through supraperiosteal injections for structural support. Elastic, moldable fillers, directly injected into superficial fat, enhance superficial layers while preserving natural mobility. Non-cross-linked formulations, used subdermally, by using a cannula, hydrate and improve skin quality, ensuring precise integration with minimal risk.
conclusionsThe multilayer technique combines different fillers in deep, superficial, and dermal layers, tailored to the patient's anatomy. This three-layer method restores volume and preserves natural expression, simultaneously improving skin quality, particularly benefiting hollow or mature faces. Unlike single-plane injections, it addresses all aging aspects. Although not yet routine, ultrasound integration in multilayer treatments promises higher efficacy and safety. This approach marks a significant advancement in modern facial rejuvenation standards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.