Evidence map›Paper›PMID 41532882›Full record

ArticleChemistry & biodiversity2026

Exploring the Potential of Morus nigra L. Fruit and Leaves as Food Additives: Antioxidant, Antiproliferative, Enzyme Inhibition Effects, and Phytochemical Profiles.

Rana Elif Akkuş, Zühal Bayrakçeken Güven, Mustafa Abdullah Yilmaz, Oguz Cakir

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rana Elif AkkuşDepartment of Pharmaceutical Sciences, Erzincan Binali Yıldırım University, Institute of Health Sciences, Erzincan, Türkiye.
Zühal Bayrakçeken GüvenDepartment of Pharmacognosy, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Türkiye.ORCID https://orcid.org/0000-0003-3405-6996
Mustafa Abdullah YilmazDepartment of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakir, Türkiye.
Oguz CakirDicle University Science and Technology Application and Research Center (DUBTAM), Diyarbakir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morus nigra has been used in folk medicine and as food since ancient times. In this study, the cytotoxic, antioxidant, urease enzyme, and enzymatic browning inhibitory effects of the fruits and pruning by-product leaves were investigated, and their potential as food additives was evaluated. LC-MS/MS analysis showed that quinic acid (48.904 mg/g extract) was present in the highest amount in the fruit, while isoquercitrin (20.38 mg/g extract) was present in the highest amount in the leaves. According to the MTT method, the leaf ethyl acetate fraction (LEF) showed the highest cytotoxic effect against Hep-3B cells at 400 µg/mL with 48.20% cell viability. The antioxidant capacity of LEF is approximately three times that of Trolox and half that of gallic acid. LEF inhibited urease with IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsEnzyme InhibitorsFood AdditivesMorusPhytochemicalsPlant ExtractsBiphenyl CompoundsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFruitHumansMonophenol Monooxygenase1,1-diphenyl-2-picrylhydrazylAntineoplastic Agents, PhytogenicAntioxidantsBiphenyl CompoundsEnzyme InhibitorsFood AdditivesMonophenol MonooxygenasePhytochemicalsPicratesPlant ExtractsUreaseantioxidantLC–MS/MSMorus nigraMTTtyrosinase

Identifiers

PMID41532882
PMCPMC13420227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.