Evidence map›Paper›PMID 41532857›Full record

ArticleThe Journal of physiology2026

Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.

Chloe Cable, Sidney P Kuo, Eric A Newman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chloe CableDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-6878-5698
Sidney P KuoDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Eric A NewmanDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9296-6237

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FERRINGTON, DEBORAH ANN · 1996 to 2019
$8.8M
Astrocyte regulation of cerebral blood flow during hypoglycemiaR01NS126166 · NINDS · UNIVERSITY OF MINNESOTA · PI ERIC A NEWMAN · 2022 to 2026
$1.9M
Regulation of Capillary Blood Flow in the Retina in Health and in Diabetic RetinopathyR01EY026514 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.9M
Glial cell regulation of blood flow in capillariesR01EY026882 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.7M
Muller glial cell pathophysiology during glaucoma onsetR21EY033932 · NEI · UNIVERSITY OF MINNESOTA · PI KUO, SIDNEY P · 2023 to 2024
$426k
Glial Modulation of Electrical Synapses in the RetinaF31EY031578 · NEI · UNIVERSITY OF MINNESOTA · PI CABLE, CHLOE E · 2020 to 2022
$122k
NEI NIH HHS F31 EY031578NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY026514NEI NIH HHS R01 EY026882NEI NIH HHS R21 EY033932NINDS NIH HHS R01 NS126166
6 · The paper itself

Abstract

Retinal AII amacrine cells are extensively coupled together by electrical synapses. Changes to the strength of these synapses affect how signals are routed through rod and cone retinal pathways during scotopic and photopic vision. Plasticity at these electrical synapses has not, to date, been characterized using electrophysiological approaches. We investigated the effects of NMDA receptor (NMDAR) activation on electrical coupling between AII cells using dual whole-cell patch-clamp electrophysiology in mouse retinal slices. NMDAR activation substantially decreased junctional conductance between AII cells. Relieving the Mg

Indexed as

Amacrine CellsElectrical SynapsesReceptors, N-Methyl-D-AspartateAnimalsFemaleGlycineMaleMiceMice, Inbred C57BLRetinaSerineGlycineReceptors, N-Methyl-D-AspartateSerined‐serinegap junctional conductanceglycineNMDA receptorsretinal amacrine cells

Identifiers

PMID41532857
PMCPMC12871922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.