Evidence map›Paper›PMID 41532848›Full record

ArticleChemistry & biodiversity2026

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study.

Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juniel Cruz SilvaBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Maria Gabriela Araújo MendesAdvanced Study Group in Medical Mycology, GEAMICOL, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Paulo Sérgio de Araujo SousaBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Alyne Rodrigues de Araújo NobreBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Michel Muálem de Moraes AlvesLaboratory of Antileishmania Activity, LAA), Medicinal Plants Research Center, NPPM, Federal University of Piauí, UFPI), Teresina, Brazil.
Fernando Aécio de Amorim CarvalhoLaboratory of Antileishmania Activity, LAA), Medicinal Plants Research Center, NPPM, Federal University of Piauí, UFPI), Teresina, Brazil.
Tatiane Caroline DaboitAdvanced Study Group in Medical Mycology, GEAMICOL, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
José de Sousa Lima NetoPharmacy Department, Health Sciences Center, Federal University of Piauí (UFPI), Teresina, Brazil.
Ygor Victor Ferreira PinheiroBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Ytallo da Costa SousaBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Edymilaís da Silva SousaOrganic Geochemistry Laboratory, Natural Sciences Center, Federal University of Piauí (UFPI), Teresina, Brazil.
José Delano Barreto Marinho FilhoDelta Cell Culture Laboratory, LCCDelta), Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Ana Jérsia AraújoDelta Cell Culture Laboratory, LCCDelta), Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Francisco Artur Silva FilhoState University of Piauí, Parnaíba, Brazil.
Sidney Gonçalo de LimaAdvanced Study Group in Medical Mycology, GEAMICOL, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.
Leiz Maria Costa VérasBiodiversity and Biotechnology Research Center, BIOTEC, Federal University of Delta do Parnaíba (UFDPAR), Parnaíba, Brazil.ORCID https://orcid.org/0000-0003-3422-2878

Funding

CNPq
6 · The paper itself

Abstract

The essential oil of Pilocarpus microphyllus (jaborandi) (EOJ), a species traditionally recognized for its alkaloid-based pharmacological properties, remains poorly investigated despite its richness in bioactive terpenes. In this study, the chemical profile of EOJ obtained from fresh and dried leaves was determined by gas chromatography-mass spectrometry, revealing 24 constituents, predominantly γ-cadinene (23.6%) and trans-caryophyllene (22.9%). Antifungal activity was observed against Cryptococcus neoformans (minimum inhibitory concentration: 149-2395 µg/mL), while antileishmanial potential was confirmed against Leishmania amazonensis promastigotes (half-maximal inhibitory concentration [IC

Indexed as

Antiprotozoal AgentsOils, VolatilePilocarpusAntifungal AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic Agents, PhytogenicCell Line, TumorComputer SimulationCryptococcus neoformansDose-Response Relationship, DrugGas Chromatography-Mass SpectrometryHumansIn Vitro TechniquesLeishmaniaLeishmaniasisMolecular Docking SimulationAntifungal AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic Agents, PhytogenicAntiprotozoal Agentscaryophyllenegamma-cadineneOils, VolatilePolycyclic Sesquiterpenescytotoxicitymolecular dockingPilocarpus microphyllustrans‐caryophylleneγ‐cadinene

Identifiers

PMID41532848
PMCPMC12802534

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.