Evidence map›Paper›PMID 41532818›Full record

ArticleChemistry & biodiversity2026

Exploring Molecular Mechanism of Thymoquinone via cMet and PDGFR for Accelerated Hemostasis: An Approach Through In Silico, In Vitro, and In Vivo Studies.

Ankit Majie, Pran Kishore Deb, Wei Meng Lim, Santanu Ghosh, Bapi Gorain

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ankit MajieDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Pran Kishore DebDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Wei Meng LimSchool of Pharmacy, Monash University, Bandar Sunway, Subang Jaya, Malaysia.
Santanu GhoshDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Bapi GorainDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.ORCID https://orcid.org/0000-0002-8487-1748

Funding

Indian Council of Medical Research
6 · The paper itself

Abstract

Modulation of coagulation activity by thymoquinone (TQ), a 1,4-benzoquinone derivative of Nigella sativa, prompted the identification and validation of a molecular mechanism for hemostasis. Consequently, this research utilizes network pharmacology, molecular docking, and dynamics approaches to investigate the role of TQ for improved hemostasis. Initially, protein targets related to hemostasis and TQ were extracted, where the common targets were subjected to KEGG pathway enrichment and gene ontology analysis to determine the top pathways responsible for inducing hemostasis. The key protein targets from the identified pathways were selected for molecular docking and MM-GBSA calculations, where the targets with the highest absolute Glide docking and ΔG

Indexed as

BenzoquinonesHemostasisAnimalsHumansMaleMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureRatsBenzoquinonesthymoquinonecMethemostasis activityPDGFRrat tail hemorrhage modelthymoquinone

Identifiers

PMID41532818
PMCPMC13420240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.