Evidence map›Paper›PMID 41532769›Full record

ArticleAntimicrobial agents and chemotherapy2026

Characterization of a novel monoclonal antibody candidate that targets bacterial GAPDH and protects neonatal mice from infections caused by

Carolina Fernandes, Filipa Lemos, Liliana Curado, Bruno L Victor, Maelenn Chevreuil, Inês Machado, Sofia Teixeira, Maria do Carmo Koch, Marta Vieira, Patrick England and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carolina Fernandes *Immunethep, Biocant Park, Cantanhede, Portugal.ORCID 0009-0004-5797-4153
Filipa Lemos *Immunethep, Biocant Park, Cantanhede, Portugal.
Liliana CuradoImmunethep, Biocant Park, Cantanhede, Portugal.
Bruno L VictorAccelbio: Collaborative Laboratory to Foster Translation and Drug Discovery, Cantanhede, Portugal.
Maelenn ChevreuilPlateforme de Biophysique Moléculaire, Institut Pasteur, CNRS UMR3528, Paris, France.
Inês MachadoServiço de Imuno-hemoterapia, Centro Hospitalar e Universitário de São João, Porto, Portugal.
Sofia TeixeiraServiço de Imuno-hemoterapia, Centro Hospitalar e Universitário de São João, Porto, Portugal.
Maria do Carmo KochServiço de Imuno-hemoterapia, Centro Hospitalar e Universitário de São João, Porto, Portugal.
Marta VieiraImmunethep, Biocant Park, Cantanhede, Portugal.ORCID 0000-0002-1245-5112
Patrick EnglandPlateforme de Biophysique Moléculaire, Institut Pasteur, CNRS UMR3528, Paris, France.ORCID 0000-0001-6410-5918
Pedro MadureiraImmunethep, Biocant Park, Cantanhede, Portugal.ORCID 0000-0003-4078-800X
Pedro CastanheiraImmunethep, Biocant Park, Cantanhede, Portugal.ORCID 0000-0001-6764-1783

Funding

European Union Horizon 2020 research and innovation programme 101004806MOSBRI project under the Trans-National Access (TNA) project MOSBRI-2021-15
6 · The paper itself

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a highly conserved bacterial enzyme essential for glycolysis, yet it also plays important non-metabolic, "moonlighting" roles, including host immunomodulation. Here, we describe the generation and characterization of a monoclonal antibody (mAb01) that targets extracellular GAPDH from

Indexed as

Antibodies, MonoclonalGlyceraldehyde-3-Phosphate DehydrogenasesPneumococcal InfectionsStreptococcal InfectionsStreptococcus agalactiaeStreptococcus pneumoniaeAnimalsAnimals, NewbornBacterial ProteinsFemaleHumansMiceMice, Inbred BALB CSepsisAntibodies, MonoclonalBacterial ProteinsGlyceraldehyde-3-Phosphate Dehydrogenasesbacterial sepsisGAPDHmonoclonal antibodyStreptococcus

Identifiers

PMID41532769
PMCPMC12888860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.