Evidence map›Paper›PMID 41532767›Full record

ArticleAntimicrobial agents and chemotherapy2026

Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model.

Marin Lahouati, Vasco Dias Meireles, Camille Rougnon-Glasson, Antoine Petitcollin, Fabien Xuereb

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Delafloxacin: what does a new fluoroquinolone offer?Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marin LahouatiHôpital Pellegrin, Service de pharmacie clinique, CHU de Bordeaux, Bordeaux, France.ORCID 0000-0003-0043-7336
Vasco Dias MeirelesHôpital Pellegrin, Service de pharmacie clinique, CHU de Bordeaux, Bordeaux, France.
Camille Rougnon-GlassonLaboratoire de Pharmaco-Toxicologie Biologique et Médico-Légale, CH Tarbes-Lourdes, Tarbes, France.
Antoine PetitcollinHôpital Pellegrin, Service de pharmacie clinique, CHU de Bordeaux, Bordeaux, France.
Fabien XuerebHôpital Pellegrin, Service de pharmacie clinique, CHU de Bordeaux, Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) penetration of delafloxacin was evaluated in a murine model. Mice received a single 40 mg/kg intraperitoneal dose. Plasma and CSF samples were collected at five time points over 4 h and analyzed by ultra high-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Pharmacokinetic parameters, including CSF penetration ratio (AUC

Indexed as

Anti-Bacterial AgentsFluoroquinolonesAnimalsArea Under CurveChromatography, High Pressure LiquidFemaleMiceMicrobial Sensitivity TestsStaphylococcusTandem Mass SpectrometryAnti-Bacterial AgentsdelafloxacinFluoroquinolonescerebrospinal fluiddelafloxacinpharmacokinetic

Identifiers

PMID41532767
PMCPMC12888873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.