Evidence map›Paper›PMID 41532765›Full record

ArticleCancer reports (Hoboken, N.J.)2026

How Do Patient Demographics and Socioeconomic Disadvantage Impact Clinical Presentation, Surgical Outcomes, and Survival for Upper Extremity Soft Tissue Sarcoma?

Nicole J Newman-Hung, Kameel Khabaz, Michaela Juels, Giovanni Gamalong, Daniel Chiou, Bailey Mooney, Nicholas M Bernthal, Lauren E Wessel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole J Newman-HungDepartment of Orthopaedic Surgery, University of California, Los Angeles, California, USA.
Kameel KhabazDavid Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-3164-6133
Michaela JuelsDavid Geffen School of Medicine, University of California, Los Angeles, California, USA.
Giovanni GamalongDavid Geffen School of Medicine, University of California, Los Angeles, California, USA.
Daniel ChiouDepartment of Orthopaedic Surgery, University of California, Los Angeles, California, USA.
Bailey MooneyDepartment of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrence, California, USA.
Nicholas M BernthalDepartment of Orthopaedic Surgery, University of California, Los Angeles, California, USA.
Lauren E WesselDepartment of Orthopaedic Surgery, University of California, Los Angeles, California, USA.

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
NIAMS NIH HHS T32 AR059033NIAMS NIH HHS T32AR059033-12
6 · The paper itself

Abstract

backgroundSoft tissue sarcomas (STS) of the upper extremity (UE) are uncommon and may require complex surgical management. Socioeconomic disadvantage, race/ethnicity, sex, and marital status may influence presentation, surgical complexity, local recurrence (LR), and overall survival (OS).

aimsThe aim of this work is to examine the influence of socioeconomic and demographic factors on the presentation and outcomes of upper extremity soft tissue sarcomas. METHODS AND

resultsWe identified patients treated surgically for primary UE STS (2012-2022). Demographics, tumor characteristics, and outcomes were recorded. Associations between demographics and time to presentation, skin grafting, amputation, and LR were assessed using chi-square and t-tests. Competing risks regression analyzed 3- and 5-year LR, and Kaplan-Meier analysis assessed 5-year OS. Among 181 patients, the mean time to presentation was 17.1 months (SD 34.3), mean tumor size was 7.8 cm (SD 5.7) while 56% required re-excision, 15% underwent amputation, 15% required skin grafting, and 24% experienced LR. Hispanic/Latino patients presented with larger tumor sizes (9.17 ± 5.71 cm vs. 7.43 ± 5.61 cm, p = 0.037). Non-married patients had higher odds of amputation (OR 3.15, p = 0.012), and female sex predicted greater LR risk (OR 2.17, p = 0.037). Twenty-one patients (11.1%) died within five years. In multivariable analysis, increasing tumor size (OR = 1.08; p = 0.010) and high tumor grade (OR = 8.28; p = 0.038) significantly impacted 5-year OS.

conclusionWhile disparities across patient demographics may exist for surgical outcomes for UE STS, racial disparities in overall survival may be mitigated with treatment at an urban, tertiary care sarcoma center.

Indexed as

Neoplasm Recurrence, LocalSarcomaSoft Tissue NeoplasmsUpper ExtremityAdultAgedAmputation, SurgicalFemaleHumansMaleMiddle AgedRetrospective StudiesSocioeconomic Disparities in HealthSocioeconomic FactorsTreatment Outcomesocioeconomic disadvantagesoft tissue sarcomaupper extremity cancers

Identifiers

PMID41532765
PMCPMC12802082

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.