ArticlemBio2026
Synergistic regulatory mechanisms in glycolysis revealed by pathway transplantation.
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Protein allostery, present in all three domains of life, is key to the regulation of metabolism by allowing fast and precise control of catalysis in response to cellular demands. While metabolic pathways are frequently equipped with multiple allosterically regulated catalytic steps, experimental studies often focus on a single step, failing to capture how regulations exerted at multiple steps interact with each other for tuning pathways. Using the nearly ubiquitous Embden-Meyerhof-Parnas pathway of glycolysis as a paradigm, the present study unveils a remarkable regulatory synergy between multiple allosteric proteins of a metabolic pathway and demonstrates its impact on cell survival in dynamic environments. By using complete pathway complementation, as well as single-gene complementation, the essential regulatory steps were identified to be glucokinase, phosphofructokinase, and pyruvate kinase. Expression of these enzymes together, even in the context of the
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