Evidence map›Paper›PMID 41532664›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules.

Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wan Gi ByunCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.ORCID https://orcid.org/0009-0009-4720-2033
Sumin SonCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.ORCID https://orcid.org/0009-0005-2999-1260
JinAh LeeZoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, 13488, South Korea.
Minha LeeCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.
Meehyun KoZoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, 13488, South Korea.ORCID https://orcid.org/0000-0003-4412-5545
Songrui ZhaoAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.
Ju Hee KimSPARK Biopharma, Inc, Seoul, 08791, South Korea.
Kannan VaithegiCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.
Ji Hoon KwonCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.
Jung Ho LeeDepartment of Biophysics and Chemical Biology, Seoul National University, Seoul, 08826, South Korea.
Sangeun JeonZoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, 13488, South Korea.
Dawon YiDepartment of Biophysics and Chemical Biology, Seoul National University, Seoul, 08826, South Korea.
Peng ZouAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.
Seungtaek KimZoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, 13488, South Korea.
Seung Bum ParkCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, South Korea.ORCID https://orcid.org/0000-0003-1753-1433

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of emerging infectious diseases highlights the urgent need for broad-spectrum antiviral therapeutics. Here, the discovery of SB2960, a small molecule, is reported that promotes stress granule (SG) formation and exhibits potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. Target identification studies reveal that SB2960 engages receptor for activated protein C kinase 1 (RACK1), a key regulator of SG dynamics. Integrated transcriptomic and proteomic analyses further demonstrate that SB2960 alters the composition of SG and modulates the expression of antiviral genes. These findings establish SB2960 as a promising host-directed broad-spectrum antiviral agent and a valuable probe for investigating SG biology in the context of viral infection.

Indexed as

Antiviral AgentsStress GranulesAnimalsHost-Directed TherapyHumansVirus ReplicationAntiviral Agentsbroad‐spectrum antiviral agentsSARS‐CoV‐2stress granulestructure‐activity relationshiptarget identification

Identifiers

PMID41532664
PMCPMC12948273

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.